Anthrax toxins: A paradigm of bacterial immune suppression. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Anthrax toxins: A paradigm of bacterial immune suppression. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.it.2006.07.002 (literal)

Alternative label

• Baldari CT, Tonello F, Paccani SR, Montecucco C (2006)
  Anthrax toxins: A paradigm of bacterial immune suppression.
  in Trends in immunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldari CT, Tonello F, Paccani SR, Montecucco C (literal)

Pagina inizio

• 434 (literal)

Pagina fine

• 440 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S1471490606002079 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Trends in immunology (Rivista)

Note

• Scopus (literal)
• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy b Department of Biomedical Sciences, CNR Institute of Neuroscience, University of Padua, 35121 Padua, Italy (literal)

Titolo

• Anthrax toxins: A paradigm of bacterial immune suppression. (literal)

Abstract

• Several species of microorganism have developed immune evasion and/or immunosuppression strategies. Bacillus anthracis secretes two toxins, edema toxin and lethal toxin, that enter the cytosol of almost every cell type, including the cells of the innate and adaptive immune systems, and subvert cell signaling. Edema toxin causes a consistent elevation of cyclic adenosine monophosphate, whereas lethal toxin cleaves most isoforms of mitogen-activated protein kinase kinases. In a concerted manner, these toxins alter major signaling pathways involved in the development of immune-cell effector functions, with the inhibition of bacterial clearance by phagocytes and of B. anthracis-specific responses. Thus, B. anthracis can invade the host, with ensuing massive bacteremia and toxemia. Here, we review the specific effects of B. anthracis on neutrophils, macrophages, dendritic cells, T- and B-lymphocytes. (literal)

Prodotto di

• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• FIORELLA TONELLO (Unità di personale interno)
• CESARE MONTECUCCO (Persona)

Incoming links:

Autore CNR di

• CESARE MONTECUCCO (Persona)
• FIORELLA TONELLO (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Trends in immunology (Rivista)