The LGI1/Epitempin gene encodes two protein isoforms differentially expressed in human brain (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The LGI1/Epitempin gene encodes two protein isoforms differentially expressed in human brain (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1471-4159.2006.03939.x (literal)

Alternative label

• Furlan S; Roncaroli F; Forner F; Vitiello L; Calabria E; Piquer-Sirerol S; Valle G; Perez-Tur J; Michelucci R; Nobile C (2006)
  The LGI1/Epitempin gene encodes two protein isoforms differentially expressed in human brain
  in Journal of neurochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Furlan S; Roncaroli F; Forner F; Vitiello L; Calabria E; Piquer-Sirerol S; Valle G; Perez-Tur J; Michelucci R; Nobile C (literal)

Pagina inizio

• 985 (literal)

Pagina fine

• 991 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 98 (literal)

Rivista

• Journal of neurochemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-Istituto di Neuroscienze, Sezione di Padova, c/o Dipartimento di Scienze Biomediche Sperimentali, Università di Padova, Padua, Italy; Department of Neuropathology, Imperial College London, London, UK; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany; CRIBI Biotechnology Centre, Dipartimento di Biologia, Dipartimento di Scienze Biomediche Sperimentali, Università di Padova, Padua, Italy; Unitat de Genetica Molecular, Institut de Biomedicina de Valencia-CSIC, Valencia, Spain; Dipartimento di Neuroscienze, Divisione di Neurologia, Ospedale Bellaria, Bologna, Italy. (literal)

Titolo

• The LGI1/Epitempin gene encodes two protein isoforms differentially expressed in human brain (literal)

Abstract

• The leucine-rich, glioma inactivated 1 (LGI1)/Epitempin gene has been linked to two phenotypes as different as gliomagenesis and autosomal dominant lateral temporal epilepsy. Its function and the biochemical features of the encoded protein are unknown. We characterized the LGI1/Epitempin protein product by western blot analysis of mouse and human brain tissues. Two proteins of about 60 and 65 kDa were detected by an anti-LGI1 antibody within the expected molecular mass range. The two proteins appeared to reside in different subcellular compartments, as they were fractionated by differential centrifugation. The specificity of both polypeptides was validated by cell transfection assay and mass spectrometry analysis. Immunoblot analysis of protein distribution in various zones of the human brain revealed variable amounts of both proteins. Notably, these proteins were more abundant in the temporal neocortex than in the hippocampus, the difference in abundance of the 65-kDa product being particularly pronounced. These results suggest that the two protein isoforms encoded by LGI1/Epitempin are differentially expressed in the human brain, and that higher expression levels of these proteins in the lateral temporal cortex may underlie the susceptibility of this brain region to the epileptogenic effects of LGI1/Epitempinmutations (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)

Autore CNR

• SANDRA FURLAN (Persona)
• CARLO NOBILE (Unità di personale interno)

Incoming links:

Autore CNR di

• CARLO NOBILE (Unità di personale interno)
• SANDRA FURLAN (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurochemistry (Rivista)