Botulinal neurotoxins: revival of an old killer. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Botulinal neurotoxins: revival of an old killer. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.coph.2004.12.006 (literal)

Alternative label

• Montecucco C; Molgo J (2005)
  Botulinal neurotoxins: revival of an old killer.
  in Current opinion in pharmacology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Montecucco C; Molgo J (literal)

Pagina inizio

• 274 (literal)

Pagina fine

• 279 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S147148920500038X (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Current opinion in pharmacology (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Dipartimento di Scienze Biomediche, Istituto CNR di Neuroscienze, Università di Padova, Viale G. Colombo 3, 35131 Padova, Italy b Laboratoire de Neurobiologie Cellulaire et Moléculaire, C.N.R.S., Institut Fédératif de Neurobiologie Alfred Fessard, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France (literal)

Titolo

• Botulinal neurotoxins: revival of an old killer. (literal)

Abstract

• Botulinal neurotoxins (BoNTs) produced by anaerobic bacteria of the genus Clostridium are the most toxic proteins known, with mouse LD(50) values in the range of 1-5 ng/kg. They are responsible for the pathophysiology of botulism. BoNTs are metalloproteinases that enter peripheral cholinergic nerve terminals, where they cleave one or two of the three core proteins of the neuroexocytosis apparatus and elicit persistent but reversible inhibition of neurotransmitter release. Their specificity of action has made them useful therapeutic agents for many human syndromes caused by hyperactivity of cholinergic nerve terminals. Their range of clinical applications is continuously growing, and BoNT/A is being used extensively as a pharmaco-cosmetic. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• CESARE MONTECUCCO (Persona)

Incoming links:

Autore CNR di

• CESARE MONTECUCCO (Persona)

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current opinion in pharmacology (Rivista)