A novel potassium channel in lymphocyte mitochondria. (Articolo in rivista)

Type
Label
  • A novel potassium channel in lymphocyte mitochondria. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1074/jbc.M413548200 (literal)
Alternative label
  • Szabò I; Bock J; Jeckle A; Soddeman M; Adams C; Lang F; Zoratti M; Gulbins E (2005)
    A novel potassium channel in lymphocyte mitochondria.
    in The Journal of biological chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Szabò I; Bock J; Jeckle A; Soddeman M; Adams C; Lang F; Zoratti M; Gulbins E (literal)
Pagina inizio
  • 12790 (literal)
Pagina fine
  • 12798 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.jbc.org/content/280/13/12790.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 280 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 13 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Szabò I: Dipartimento di Biologia, Università di Padova. Bock J: Dept. of Internal Medicine, University of Regensburg, Germany. Soddeman M; Adams C; Gulbins E: Department of Molecular Biology, University of Essen, Germany. Jeckle A; Lang F: Department of Physiology, University of Tuebingen, Germany (literal)
Titolo
  • A novel potassium channel in lymphocyte mitochondria. (literal)
Abstract
  • The margatoxin-sensitive Kv1.3 is the major potassium channel in the plasma membrane of T lymphocytes. Electron microscopy, patch clamp, and immunological studies identified the potassium channel Kv1.3, thought to be localized exclusively in the cell membrane, in the inner mitochondrial membrane of T lymphocytes. Patch clamp of mitoplasts and mitochondrial membrane potential measurements disclose the functional expression of a mitochondrial margatoxin-sensitive potassium channel. To identify unambiguously the mitochondrial localization of Kv1.3, we employed a genetic model and stably transfected CTLL-2 cells, which are genetically deficient for this channel, with Kv1.3. Mitochondria isolated from Kv1.3-reconstituted CTLL-2 expressed the channel protein and displayed an activity, which was identical to that observed in Jurkat mitochondria, whereas mitochondria of mock-transfected cells lacked a channel with the characteristics of Kv1.3. Our data provide the first molecular identification of a mitochondrial potassium conductance. (literal)
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