http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37951
Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control. (Articolo in rivista)
- Type
- Label
- Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1242/dev.01855 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Resta V; Novelli E; Di Virgilio F; Galli-Resta L. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Neuroscienze CNR PISA (literal)
- Titolo
- Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control. (literal)
- Abstract
- The precise assembly of neuronal circuits requires that the
correct number of pre- and postsynaptic neurons form
synaptic connections. Neuronal cell number is thus tightly
controlled by cell death during development. Investigating
the regulation of cell number in the retina we found an ATP
gated mechanism of neuronal death control. By degrading
endogenous extracellular ATP or blocking the P2X7 ATP
receptors we found that endogenous extracellular ATP
triggers the death of retinal cholinergic neurons during
normal development. ATP-induced death eliminates
cholinergic cells too close to one another, thereby
controlling the total number, the local density and the
regular spacing of these neurons. (literal)
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