Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Padmanabhan Paranji Pattabiraman, Daniela Tropea, Cristina Chiaruttini, Enrico Tongiorgi, Antonino Cattaneo, Luciano Domenici (2005)
  Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo.
  in Molecular and cellular neurosciences (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Padmanabhan Paranji Pattabiraman, Daniela Tropea, Cristina Chiaruttini, Enrico Tongiorgi, Antonino Cattaneo, Luciano Domenici (literal)

Pagina inizio

• 556 (literal)

Pagina fine

• 570 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• Molecular and cellular neurosciences (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Padmanabhan Paranji Pattabiraman , Antonino Cattaneo, Luciano Domenici: Neuroscience Program, International School for Advanced Studies (SISSA/ISAS), Trieste 34014, Italy. Daniela Tropea: DBCS, MIT, Cambridge, MA, USA Cristina Chiaruttini, Enrico Tongiorgi: Department of Biology, Brain Centre for Neuroscience, University of Trieste, Trieste 34127, Italy Luciano Domenici: Institute of Neuroscience (CNR), Pisa, Italy (literal)

Titolo

• Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. (literal)

Abstract

• Activity-dependent changes in BDNF expression have been implicated in developmental plasticity. Although its expression is widespread in visual cortex, developmental regulation of its different transcripts by visual experience has not been investigated. Here, we investigated the cellular expression of different BDNF transcripts in rat visual cortex during postnatal development. We found that transcripts I and II are expressed only in adults but III and IV are expressed from early postnatal stage. Total BDNF mRNA is expressed throughout the age groups. Transcripts III and IV show a differential intracellular localization, while former was detected only in cell bodies, latter is present both in cell bodies and dendritic processes. Inhibition of visual activity decreases the levels of exons, with exon IV transcript almost disappearing from dendrites. In vitro experiments also confirmed the above results, indicating activity-dependent regulation of different BDNF promoters with specific temporal and cellular patterns of expression in developing visual cortex. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Plasticità e invecchiamento del sistema nervoso (ME.P02.006.001) (Modulo)

Autore CNR

• LUCIANO DOMENICI (Persona)

Insieme di parole chiave

• Keywords of "Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Plasticità e invecchiamento del sistema nervoso (ME.P02.006.001) (Modulo)

Autore CNR di

• LUCIANO DOMENICI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular and cellular neurosciences (Rivista)

Insieme di parole chiave di

• Keywords of "Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo." (Insieme di parole chiave)