Regulation of peripheral T cell activation by calreticulin. (Articolo in rivista)

Type
Label
  • Regulation of peripheral T cell activation by calreticulin. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1084/jem.20051519 (literal)
Alternative label
  • Porcellini S, Traggiai E, Schenk U, Ferrera D, Matteoli M, Lanzavecchia A, Michalak M and Grassi F (2006)
    Regulation of peripheral T cell activation by calreticulin.
    in The Journal of experimental medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Porcellini S, Traggiai E, Schenk U, Ferrera D, Matteoli M, Lanzavecchia A, Michalak M and Grassi F (literal)
Pagina inizio
  • 461 (literal)
Pagina fine
  • 471 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 203 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Inst Res Biomed, CH-6500 Bellinzona, Switzerland 2. CNR, Ctr Excellence Neurodegenerat Dis, Dept Med Pharmacol, Inst Neurosci Cellular & Mol Pharmacol, I-20129 Milan, Italy 3. Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada (literal)
Titolo
  • Regulation of peripheral T cell activation by calreticulin. (literal)
Abstract
  • Regulated expression of positive and negative regulatory factors controls the extent and duration of T cell adaptive immune response preserving the organism's integrity. Calreticulin (CRT) is a major Ca(2+) buffering chaperone in the lumen of the endoplasmic reticulum. Here we investigated the impact of CRT deficiency on T cell function in immunodeficient mice reconstituted with fetal liver crt(-/-) hemopoietic progenitors. These chimeric mice displayed severe immunopathological traits, which correlated with a lower threshold of T cell receptor (TCR) activation and exaggerated peripheral T cell response to antigen with enhanced secretion of inflammatory cytokines. In crt(-/-) T cells TCR stimulation induced pulsatile cytosolic elevations of Ca(2+) concentration and protracted accumulation of nuclear factor of activated T cells in the nucleus as well as sustained activation of the mitogen-activated protein kinase pathways. These observations support the hypothesis that CRT-dependent shaping of Ca(2+) signaling critically contributes to the modulation of the T cell adaptive immune response. (literal)
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