Brain nicotinic acetylcholine receptors: native subtypes and their relevance. (Articolo in rivista)

Type
Label
  • Brain nicotinic acetylcholine receptors: native subtypes and their relevance. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.tips.2006.07.004 (literal)
Alternative label
  • Gotti C (1), Zoli M (2) and Clementi F(1) (2006)
    Brain nicotinic acetylcholine receptors: native subtypes and their relevance.
    in Trends in pharmacological sciences (Regular ed., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gotti C (1), Zoli M (2) and Clementi F(1) (literal)
Pagina inizio
  • 482 (literal)
Pagina fine
  • 491 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 27 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. CNR, Inst Neurosci Cellular & Mol Pharmacol, Dept Med Pharmacol,Univ Milan, I-20129 Milan, Italy 2. Univ Modena, Dept Biomed Sci, Physiol Sect, I-41100 Modena, (literal)
Titolo
  • Brain nicotinic acetylcholine receptors: native subtypes and their relevance. (literal)
Abstract
  • Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic channels that is present throughout the nervous system. These channels are involved both in physiological functions (including cognition, reward, motor activity and analgesia) and in pathological conditions such as Alzheimer's disease, Parkinson's disease, some forms of epilepsy, depression, autism and schizophrenia. They are also the targets of tobacco-smoking effects and addiction. Neuronal nicotinic acetylcholine receptors are pentamers of homomeric or heteromeric combinations of alpha (alpha 2-alpha 10) and beta (beta 2-beta 4) subunits, which have different pharmacological and biophysical properties and locations in the brain. The lack of subtype-specific ligands and the fact that many neuronal cells express multiple subtypes initially hampered the identification of the different native nicotinic acetylcholine receptor subtypes, but the increasing knowledge of subtype composition and roles will be of considerable interest for the development of new and clinically useful nicotinic acetylcholine receptor ligands (literal)
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