New adenosine A2A receptor antagonists: actions on Parkinson's disease models (Articolo in rivista)

Type
Label
  • New adenosine A2A receptor antagonists: actions on Parkinson's disease models (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejphar.2005.01.057 (literal)
Alternative label
  • Pinna A., Volpini R., Cristalli G., Morelli M (2005)
    New adenosine A2A receptor antagonists: actions on Parkinson's disease models
    in European journal of pharmacology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pinna A., Volpini R., Cristalli G., Morelli M (literal)
Pagina inizio
  • 157 (literal)
Pagina fine
  • 164 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 512 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR Institute for Neuroscience--Section Cagliari, Cagliari, Italy Department of Toxicology, University of Cagliari, Via Ospedale, 72 09124 Cagliari, Italy Department Chemical Sciences, University of Camerino, Camerino, Italy (literal)
Titolo
  • New adenosine A2A receptor antagonists: actions on Parkinson's disease models (literal)
Abstract
  • The 8-substituted 9-ethyladenine derivatives: 8-bromo-9-ethyladenine (ANR 82), 8-ethoxy- 9-ethyladenine (ANR 94), and 8-furyl-9- ethyladenine (ANR 152) have been characterized in vitro as adenosine receptor antagonists. Adenosine is deeply involved in the control of motor behaviour and substantial evidences indicate that adenosine A2A receptor antagonists improve motor deficits in animal models of Parkinson's disease. On this basis, the efficacy of ANR 82, ANR 94, and ANR 152 in rat models of Parkinson's disease was evaluated. All compounds tested reversed the catalepsy induced by haloperidol. However, in unilaterally 6-hydroxydopamine-lesioned rats, only ANR 94 and ANR 152 potentiated l-dihydroxy-phenylalanine (l-DOPA) effect on turning behaviour and induced contralateral turning behaviour in rats sensitised to l-DOPA. Taken together the results of this study indicate that some 8-substituted 9-ethyladenine derivatives ameliorate motor deficits in rat models of Parkinson's disease, suggesting a potential therapeutic role of these compounds. (literal)
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