Potent inhibitors of anthrax lethal factor from green tea. (Articolo in rivista)

Type
Label
  • Potent inhibitors of anthrax lethal factor from green tea. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.embor.7400118 (literal)
Alternative label
  • Dell'Aica I, Dona M, Tonello F, Piris A, Mock M, Montecucco C, Garbisa S (2004)
    Potent inhibitors of anthrax lethal factor from green tea.
    in EMBO reports (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dell'Aica I, Dona M, Tonello F, Piris A, Mock M, Montecucco C, Garbisa S (literal)
Pagina inizio
  • 418 (literal)
Pagina fine
  • 422 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299029/?tool=pubmed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Dipartimento di Scienze Biomediche, Università di Padova, Padova, Italy 2Istituto CNR di Neuroscienze, Padova, Italy 3Toxines et Pathogénie Bactérienne (CNRS URA 2172), Institut Pasteur, Paris, France (literal)
Titolo
  • Potent inhibitors of anthrax lethal factor from green tea. (literal)
Abstract
  • The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the N-terminus of MAPK-kinases. PA+LF are cytotoxic to macrophages in culture and kill the Fischer 344 rat when injected intravenously. We describe here the properties of some polyphenols contained in green tea as powerful inhibitors of LF metalloproteolytic activity, and how the main catechin of green tea, (-)epigallocatechin-3-gallate, prevents the LF-induced death of macrophages and Fischer 344 rats. (literal)
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