Idiopathic partial epilepsy with auditory features (IPEAF ) a clinical and genetic study of 53 sporadic cases (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Idiopathic partial epilepsy with auditory features (IPEAF ) a clinical and genetic study of 53 sporadic cases (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Bisulli F, Tinuper P, Avoni P, Striano P, Striano S, d’Orsi G, Vignatelli L, Bagattin A, Scudellaro E, Florinfo I, Nobile C, Tassinari C.A, Baruzzi a, Michelucci R (2004)
  Idiopathic partial epilepsy with auditory features (IPEAF ) a clinical and genetic study of 53 sporadic cases
  in Brain (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bisulli F, Tinuper P, Avoni P, Striano P, Striano S, d’Orsi G, Vignatelli L, Bagattin A, Scudellaro E, Florinfo I, Nobile C, Tassinari C.A, Baruzzi a, Michelucci R (literal)

Pagina inizio

• 1343 (literal)

Pagina fine

• 1352 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 127 (literal)

Rivista

• Brain (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Neurological Sciences, University of Bologna, Bologna; , Department of Neurological Sciences, University Federico II, Naples Department of Biology. University of Padua, Padua. CNR-Neurosciences Institute. Section of Padua. Department of Neurosciences, University of Parma Department of Neurosciences, Bellaria Hospital, Bologna (literal)

Titolo

• Idiopathic partial epilepsy with auditory features (IPEAF ) a clinical and genetic study of 53 sporadic cases (literal)

Abstract

• The purpose of our study was to describe the clinical characteristics of sporadic (S) cases of partial epilepsy with auditory features (PEAF) and pinpoint clinical, prognostic and genetic differences with respect to previously reported familial (F) cases of autosomal dominant partial epilepsy with auditory features (ADPEAF). We analysed 53 patients (24 females and 29 males) with PEAF diagnosed according to the following criteria: partial epilepsy with auditory symptoms, negative family history for epilepsy and absence of cerebral lesions on NMR study. All patients underwent a full clinical, neuroradiological and neurophysiological examination. Forty patients were screened for mutations in LGI1/epitempin, which is involved in ADPEAF. Age at onset ranged from 6 to 39 years (average 19 years). Secondarily generalized seizures were the most common type of seizures at onset (79%). Auditory auras occurred either in isolation (53%) or associated with visual, psychic or aphasic symptoms. Low seizure frequency at onset and good drug responsiveness were common, with 51% of patients seizure-free. Seizures tended to recur after drug withdrawal. Clinically, no major differences were found between S and F patients with respect to age at onset, seizure frequency and response to therapy. Analysis of LGI1/epitempin exons failed to disclose mutations. Our data support the existence of a peculiar form of non-lesional temporal lobe epilepsy closely related to ADPEAF but without a positive family history. This syndrome, here named IPEAF, has a benign course in the majority of patients and could be diagnosed by the presence of auditory aura. Although LGI1 mutations have been excluded, genetic factors may play an aetiopathogenetic role in at least some of these S cases. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)

Autore CNR

• CARLO NOBILE (Unità di personale interno)

Incoming links:

Autore CNR di

• CARLO NOBILE (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain (Rivista)