The T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Christoffels VM, Hoogaars WMH, Tessari A., Clout DEW, Moorman AFM, Campione M (2004)
  The T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
  in Developmental dynamics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Christoffels VM, Hoogaars WMH, Tessari A., Clout DEW, Moorman AFM, Campione M (literal)

Pagina inizio

• 763 (literal)

Pagina fine

• 770 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 229 (literal)

Rivista

• Developmental dynamics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR- Institute of Neurosciences (literal)

Titolo

• The T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers (literal)

Abstract

• Specific regions of the embryonic heart tube differentiate into atrial and ventricular chamber myocardium, whereas the inflow tract, atrioventricular canal, inner curvatures, and outflow tract do not. These regions express Tbx2, a transcriptional repressor. Here, we tested its role in chamber formation. The temporal and spatial pattern of Tbx2 mRNA and protein expression in mouse hearts was found to be complementary to that of chamber myocardiumspecific genes Nppa, Cx40, Cx43, and Chisel, and was conserved in human. In vitro, Tbx2 repressed the activity of regulatory fragments of Cx40, Cx43, and Nppa. Hearts of transgenic embryos that expressed Tbx2 in the prechamber myocardium completely failed to form chambers and to express the chamber myocardium-specific genes Nppa, Cx40, and Chisel, whereas other cardiac genes were normally expressed. These findings provide the first evidence that Tbx2 is a determinant in the local repression of chamber-specific gene expression and chamber differentiation. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)

Autore CNR

• MARINA CAMPIONE (Unità di personale interno)

Incoming links:

Autore CNR di

• MARINA CAMPIONE (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Developmental dynamics (Rivista)