http://www.cnr.it/ontology/cnr/individuo/prodotto/ID37685
Baclofen: a new drug for the treatment of alcohol dependence (Articolo in rivista)
- Type
- Label
- Baclofen: a new drug for the treatment of alcohol dependence (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10. 1111 / j .1742-1241 .2006. 01065. x (literal)
- Alternative label
Addolorato G., Leggio L., Agabio R., Colombo G., Gasbarrini G (2006)
Baclofen: a new drug for the treatment of alcohol dependence
in International journal of clinical practice (Esher)
(literal)
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- Addolorato G., Leggio L., Agabio R., Colombo G., Gasbarrini G (literal)
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- ISI Web of Science (WOS) (literal)
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- Institute of Internal Medicine, Catholic University of Rome, Rome, Italy; Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy; C.N.R. Institute of Neuroscience, Cagliari, Italy (literal)
- Titolo
- Baclofen: a new drug for the treatment of alcohol dependence (literal)
- Abstract
- Recent preclinical and clinical studies have suggested that baclofen, the prototypic GABAB receptor agonist, is a promising pharmacological compound for use in the treatment of alcohol dependence. In particular, baclofen has been found to suppress symptoms of alcohol withdrawal syndrome with an efficacy comparable to that of the \"gold standard\" diazepam. Moreover baclofen has proven effective in the prevention of relapse due to its ability to reduce alcohol intake and craving in alcoholic patients. Baclofen proved to be manageable, producing no significant side effects and displaying no addictive properties. The efficacy of the drug in the management of both alcohol withdrawal syndrome and relapse prevention should entail a vastly simplified pharmacotherapy of alcohol dependence. (literal)
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