Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Serra S. 1,2, Vacca G. 1,2, Tumatis S. 1, Carrucciu A. 1, Morazzoni P. 3, Bombardelli E. 3, Colombo G. 2, Gessa G.L. 1,2,4, Carai M.A.M. 1 (2003)
  Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats.
  in Journal of ethnopharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Serra S. 1,2, Vacca G. 1,2, Tumatis S. 1, Carrucciu A. 1, Morazzoni P. 3, Bombardelli E. 3, Colombo G. 2, Gessa G.L. 1,2,4, Carai M.A.M. 1 (literal)

Pagina inizio

• 249 (literal)

Pagina fine

• 252 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 88 (literal)

Rivista

• Journal of ethnopharmacology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats. (literal)

Abstract

• Salvia miltiorrhiza extracts have been reported to suppress acquisition and maintenance of alcohol drinking behavior in Sardinian alcohol-preferring (sP) rats. The present study investigated whether IDN 5082, a standardized extract of Salvia miltiorrhiza, was capable of preventing, in sP rats, the development of the so-called alcohol deprivation effect (ADE), i.e. the transient increase in alcohol intake that occurs in laboratory animals after a period of alcohol deprivation. Interestingly, ADE has been proposed to model alcohol relapses in human alcoholics. The acute, intragastric administration of 25, 50, and 100 mg/kg IDN 5082 resulted in the complete suppression of the extra amount of alcohol consumed during the first hour of re-access to alcohol after 7 days of deprivation. These results suggest that IDN 5082 may possess anti-relapse properties. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)

Autore CNR

• GIANCARLO COLOMBO (Persona)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Persona)

Prodotto

• Institute of neuroscience (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of ethnopharmacology (Rivista)