Genetic approach to variability of memory systems: analysis of place vs response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice (Articolo in rivista)

Type
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  • Genetic approach to variability of memory systems: analysis of place vs response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Passino E., Middei S., Restivo L., Bertaina-Anglade V., Ammassari-Teule M. (2002)
    Genetic approach to variability of memory systems: analysis of place vs response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice
    in Hippocampus (N.Y.N.Y., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Passino E., Middei S., Restivo L., Bertaina-Anglade V., Ammassari-Teule M. (literal)
Pagina inizio
  • 63 (literal)
Pagina fine
  • 750972 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • IF:4,3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Neuroscienze del CNR, Sezione di Roma, Psicobiologia e Psicofarmacologia, Fondazione Santa Lucia, IRCCS, Via Ardeatina 306, 00179 Roma, Italia (literal)
Titolo
  • Genetic approach to variability of memory systems: analysis of place vs response learning and fos-related expression in hippocampal and striatal areas of C57BL/6 and DBA/2 mice (literal)
Abstract
  • C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration ( 8 or 17 days) and extra-maze cueing conditions. The first condition consisted in a diffuse visually-cued environment (rich cueing). The second one was the same plus an explicit visual cue marking the direction of the baited arm (rich cueing plus cue). The third one was a featureless environment (poor cueing). During training, mice were released from the south arm and rewarded in the east arm. Probe trials on which mice were released from the north arm and allowed to choose either the east (place learning) or the west (response learning) arm were given either on the 9th (PT1) or the 18th (PT2) days. Strain x context differences in the activation of the dorsal hippocampus and the dorsolateral striatum were examined by analysing Fos expression following each probe trial. Results first showed that C57 were essentially place- learners whereas no learning modality was predominant in DBA except on PT2 run with the explicit cue available. Examination of Fos expression in C57 trained under “rich cueing” and the “rich cueing plus cue” condition revealed a strong and parallel increase of immunoreactivity in the hippocampus and the dorsolateral striatum following PT1 that decreased under PT2. In that strain, the similar time-course variation of c-fos expression in both areas suggests a simultaneous involvement of hippocampal-and striatal-based learning mechanisms even if those controlled by the hippocampus were prevailing on those controlled by the dorsolateral striatum. In DBA, however, the absence of any preferential learning modality was associated with (1) a consistent hippocampal activation persistent across probe trials and (2) a global superior activation of the dorsolateral striatum.. Distinct patterns of Fos expression were therefore associated with every strain-specific learning modality. In each strain, however, each modality was found to be remarkably stable whatever the training duration and the cueing conditions. (literal)
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