Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Sher E, Giovannini F, Codignola A, Passafaro M, Giorgi-Rossi P, Volsen S, Craig P, Davalli A, Carrera P. (2003)
  Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.
  in Journal of bioenergetics and biomembranes
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sher E, Giovannini F, Codignola A, Passafaro M, Giorgi-Rossi P, Volsen S, Craig P, Davalli A, Carrera P. (literal)

Pagina inizio

• 687 (literal)

Pagina fine

• 696 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• Journal of bioenergetics and biomembranes (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• IF 3,05 (literal)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications. (literal)

Abstract

• Voltage-operated calcium channels play crucial roles in stimulus-secretion coupling in pancreatic beta cells. A growing body of evidence indicates that these channels in beta cells are heterogeneous. In particular, not all the high-threshold calcium channels expressed belong to the best known L-type. In rat insulinoma cells, for example, L, N, and P/Q-type channels are present, while in human beta cells L-type and P/Q-type dominate. Where present, N-type and P/Q-type channels participate, alongside with the dominant L-type, in the control of sugar- or depolarization-induced hormone release. Distinct biophysical properties and selective modulation of the channel subtypes are likely to play important physiological roles. T-type channels are involved in beta cell apoptosis, while calcium channel autoantibodies recognizing high-threshold channels in beta cells, have been described both in neurological and diabetic patients. Subtype-selective calcium channel drugs have the potential for being beneficial in beta cell pathological states. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)

Autore CNR

• MARIA PASSAFARO (Persona)

Incoming links:

Autore CNR di

• MARIA PASSAFARO (Persona)

Prodotto

• Institute of neuroscience (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of bioenergetics and biomembranes (Rivista)