The novel skeletal muscle sarcoplasmic reticulum JP-45 protein: Molecular cloning, tissue distribution, developmental expression and interaction with alfa1.1 subunit of DHPR. (Articolo in rivista)

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  • The novel skeletal muscle sarcoplasmic reticulum JP-45 protein: Molecular cloning, tissue distribution, developmental expression and interaction with alfa1.1 subunit of DHPR. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Anderson A, Treves S, Biral D, Betto R, Sandonà D, Ronjat M, Zorzato F. (2003)
    The novel skeletal muscle sarcoplasmic reticulum JP-45 protein: Molecular cloning, tissue distribution, developmental expression and interaction with alfa1.1 subunit of DHPR.
    in The Journal of biological chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Anderson A, Treves S, Biral D, Betto R, Sandonà D, Ronjat M, Zorzato F. (literal)
Pagina inizio
  • 39987 (literal)
Pagina fine
  • 39992 (literal)
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  • 278 (literal)
Rivista
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  • 6 (literal)
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  • 41 (literal)
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  • pubblicazione su rivista internazionale (literal)
Note
  • PubMe (literal)
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  • AA, ST, FZ: Departments of Anesthesia and Research, Zentrum Fu¨ r Lehr und Forschung Kantonsspital Basel; MR: Commissariat a` l'Energie Atomique, INSERM EMI 9931, Laboratoire Canaux Ioniques et Signalisation, Grenoble; DS, Dipartimento di Scienze Biomediche, Università di Padova (literal)
Titolo
  • The novel skeletal muscle sarcoplasmic reticulum JP-45 protein: Molecular cloning, tissue distribution, developmental expression and interaction with alfa1.1 subunit of DHPR. (literal)
Abstract
  • The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. J Biol Chem. 2003 Oct 10;278(41):39987-92. JP-45 is a novel integral protein constituent of the skeletal muscle sarcoplasmic reticulum junctional face membrane. We identified its primary structure from a cDNA clone isolated from a mouse skeletal muscle cDNA library. Mouse skeletal muscle JP-45 displays over 86 and 50% identity with two hypothetical NCBI data base protein sequences from mouse tongue and human muscle, respectively. JP-45 is predicted to have a cytoplasmic domain, a single transmembrane segment followed by an intralumenal domain enriched in positively charged amino acids. Northern and Western blot analyses reveal that the protein is mainly expressed in skeletal muscle. The mRNA encoding JP-45 appears in 17-day-old mouse embryos; expression of the protein peaks during the second month of postnatal development and then decreases approximately 3-fold during aging. Double immunofluorescence of adult skeletal muscle fibers demonstrates that JP-45 co-localizes with the sarcoplasmic reticulum calcium release channel. Co-immunoprecipitation experiments with a monoclonal antibody against JP-45 show that JP-45 interacts with the alpha1.1 subunit voltage-gated calcium channel and calsequestrin. These results are consistent with the localization of JP-45 in the junctional sarcoplasmic reticulum and with its involvement in the molecular mechanism underlying skeletal muscle excitation-contraction coupling. (literal)
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