Functional interaction between opioid and cannabinoid receptors in drug self-administration. (Articolo in rivista)

Type
Label
  • Functional interaction between opioid and cannabinoid receptors in drug self-administration. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Navarro M, 1 Carrera MR, 2 Fratta W, 1 Valverde O, 2 Cossu G, 3 Fattore L, 1 Chowen JA, 2 Gomez R, 1 del Arco I, 1 Villanua MA, 1 Maldonado R, 4 Koob GF, 1 Rodriguez de Fonseca F. (2001)
    Functional interaction between opioid and cannabinoid receptors in drug self-administration.
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Navarro M, 1 Carrera MR, 2 Fratta W, 1 Valverde O, 2 Cossu G, 3 Fattore L, 1 Chowen JA, 2 Gomez R, 1 del Arco I, 1 Villanua MA, 1 Maldonado R, 4 Koob GF, 1 Rodriguez de Fonseca F. (literal)
Pagina inizio
  • 5344 (literal)
Pagina fine
  • 5350 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • I.F. 8.045 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 21 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • rivista inclusa nell'elenco ISI (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Uni Madrid 2 Uni Cagliari 3 CNR 4 La Jolla, California (USA) (literal)
Titolo
  • Functional interaction between opioid and cannabinoid receptors in drug self-administration. (literal)
Abstract
  • The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The acute administration of SR141716A, a selective central cannabinoid CB1 receptor antagonist, blocked heroin self-administration in rats, as well as morphine-induced place preference and morphine self-administration in mice. Morphine-dependent animals injected with SR141716A exhibited a partial opiate-like withdrawal syndrome that had limited consequences on operant responses for food and induced place aversion. These effects were associated with morphine-induced changes in the expression of CB1 receptor mRNA in specific nuclei of the reward circuit, including dorsal caudate putamen, nucleus accumbens, and septum. Additionally, the opioid antagonist naloxone precipitated a mild cannabinoid-like withdrawal syndrome in cannabinoid-dependent rats and blocked cannabinoid self-administration in mice. Neither SR141716A nor naloxone produced any intrinsic effect on these behavioral models. The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence. (literal)
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