Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting (Articolo in rivista)

Type
Label
  • Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bagnasco M, Tulipano G, Melis M.R, Argiolas A, Cocchi D, Muller E.E (2003)
    Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bagnasco M, Tulipano G, Melis M.R, Argiolas A, Cocchi D, Muller E.E (literal)
Pagina inizio
  • 161 (literal)
Pagina fine
  • 167 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 111 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting (literal)
Abstract
  • Ghrelin, a circulating growth-hormone releasing peptide derived from stomach, stimulates food intake through neuropeptide Y (NPY) neurons of the arcuate nucleus in the hypothalamus (ARC). We examined the effect of ghrelin microinjected into the ARC and the influence of intracerebroventricular (i.c.v.) pretreatment with a GHRH or NPY receptor antagonist on ghrelin-induced food intake in free-feeding male rats. Ghrelin (0.1-1 microg) stimulated food intake in a dose-dependent manner, and this effect was reduced by 55-60% by the Y(5) NPY receptor antagonist (10 microg i.c.v.), but not by the GHRH receptor antagonist MZ-4-71 (10 microg i.c.v.). We also evaluated the effects of passive ghrelin immunoneutralization by the microinjection of anti-ghrelin immunoglobulins (IgGs) intracerebroventricularly or directly into the ARC on food intake in free-feeding and fasted male rats. i.c.v. administration of anti-ghrelin IgGs decreased cumulative food intake over 24 h, whereas microinfusion of anti-ghrelin IgGs into the ARC induced only a short-lived (2 and 6 h) effect. Collectively, these data would indicate that centrally derived ghrelin has a major role in the control of food intake in rats and, in this context, blood-born ghrelin would be effective only in relation to its ability to reach the ARC, which is devoid of blood-brain barrier. (literal)
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