Localisation of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Localisation of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Guzzi F., Zanchetta D., Cassoni P., Guzzi V., Francolini M., Parenti M., Chini B. (2002)
  Localisation of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response.
  in Oncogene (Basingstoke)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Guzzi F., Zanchetta D., Cassoni P., Guzzi V., Francolini M., Parenti M., Chini B. (literal)

Pagina inizio

• 1658 (literal)

Pagina fine

• 1667 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Oncogene (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Localisation of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. (literal)

Abstract

• In this study, we investigated the functional role of the localisation of human OTR in caveolin-1 enriched membrane domains. Biochemical fractionation of MDCK cells stably expressing the WT OTR-GFP indicated that only minor quantities of receptor are partitioned in caveolin-1 enriched domains. However, when fused to caveolin-2, the OTR protein proved to be exclusively localised in caveolin-1 enriched fractions, where it bound the agonist with increased affinity and efficiently coupled to Gaq/11. Interestingly, the chimeric protein was unable to undergo agonist- induced internalisation and remained confined to the plasma membrane even after prolonged agonist exposure (120 min). A striking difference in receptor stimulation was observed when the OT-induced effect on cell proliferation was analysed: stimulation of the human WT OTR inhibited cell growth, whereas the chimeric protein had a proliferative effect. These data indicate that the localisation of human OTR in caveolin-1 enriched microdomains radically alters its regulatory effects on cell growth; the fraction of OTR residing in caveolar structures may therefore play a crucial role in regulating cell proliferation. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Oncogene (Rivista)