LocusZoom: Regional visualization of genome-wide association scan results (Articolo in rivista)

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Label
  • LocusZoom: Regional visualization of genome-wide association scan results (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Randall J. Pruim, Ryan P. Welch, Serena Sanna , Tanya M. Teslovich , Peter S. Chines , Terry P. Gliedt , Michael Boehnke, Gonçalo R. Abecasis and Cristen J. Willer (2010)
    LocusZoom: Regional visualization of genome-wide association scan results
    in Bioinformatics (Oxf., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Randall J. Pruim, Ryan P. Welch, Serena Sanna , Tanya M. Teslovich , Peter S. Chines , Terry P. Gliedt , Michael Boehnke, Gonçalo R. Abecasis and Cristen J. Willer (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • A web tool for plotting GWAS results. Available at http://csg.sph.umich.edu/locuszoom/ (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Mathematics and Statistics, Calvin College, Grand Rapids, MI 49546 2Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109 3Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy 09042. 4Bioinformatics Graduate Program, The University of Michigan Medical School, Ann Arbor, MI 48109. 5 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland (literal)
Titolo
  • LocusZoom: Regional visualization of genome-wide association scan results (literal)
Abstract
  • Summary: Genome-wide association studies (GWAS) have revealed hundreds of loci associated with common human genetic diseases and traits. We have developed a web-based plotting tool that provides fast visual display of GWAS results in a publication-ready format. LocusZoom visually displays regional information such as the strength and extent of the association signal relative to genomic position, local linkage disequilibrium (LD) and recombination patterns, and the positions of genes in the region. Availability: LocusZoom can be accessed from a web interface at http://csg.sph.umich.edu/locuszoom. Users may generate a single plot using a web form, or many plots using batch mode. The software utilizes LD information from HapMap Phase II (CEU, YRI and JPT+CHB) or 1000 Genomes (CEU) and gene information from the UCSC browser, and will accept SNP identifiers in dbSNP or 1000 Genomes format. Single plots are generated in ~20 seconds. Source code and associated databases are available for download and local installation, and full documentation is available online. (literal)
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