Consensus on the use of substituted benzamides in psychiatric patients. (Articolo in rivista)

Type
Label
  • Consensus on the use of substituted benzamides in psychiatric patients. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1159/000079104 (literal)
Alternative label
  • Racagni G, Canonico PL, Ravizza L, Pani L, Amore M. (2004)
    Consensus on the use of substituted benzamides in psychiatric patients.
    in Neuropsychobiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Racagni G, Canonico PL, Ravizza L, Pani L, Amore M. (literal)
Pagina inizio
  • 134 (literal)
Pagina fine
  • 143 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 50 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Center of Neuropharmacology, University of Milan, Milan, DISCAFF Department, University of Piemonte Orientale, Novara, Department of Neuroscience, Psychiatric Section, University of Turin, Turin, Center for Neuropharmacology, National Research Council, Neuroscienze Scarl, Cagliari, and Institute of Psychiatry, University of Parma, Ugolino Hospital Parma, Parma, Italy (literal)
Titolo
  • Consensus on the use of substituted benzamides in psychiatric patients. (literal)
Abstract
  • The class of substituted benzamides includes compounds able to modulate dopaminergic neurons selectively and specifically. The first synthetic substituted benzamide was sulpiride, which has been replaced in the clinic by the more modern amisulpride. The compound is very selective for mesolimbic D2 and D3 receptors and, therefore, has a dual mechanism of action, which is associated with two different indications. At low doses (50 mg), amisulpride preferentially blocks presynaptic autoreceptors, producing an increase in dopamine release, and therefore acting as a dopaminergic compound able to resolve the dopaminergic hypoactivity that characterizes depression. At higher doses (400-1,200 mg), the drug exerts its activity on postsynaptic D3/D2 receptors located in the limbic region and prefrontal areas, producing selective dopaminergic inhibition, eliciting antipsychotic effects. In the present review, the clinical use of amisulpride in depressive syndromes is discussed, in particular in dysthymia and in schizophrenia. Based on experimental data, amisulpride is a treatment of choice for dopaminergic transmission disorders, both in depression and in schizophrenia. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it