Structure and organization of phospholipid/polysaccharide nanoparticles (Articolo in rivista)

Type
Label
  • Structure and organization of phospholipid/polysaccharide nanoparticles (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gerelli, Y; Di Bari, MT; Deriu, A; Cantu, L; Colombo, P; Como, C; Motta, S; Sonvico, F; May, R (2008)
    Structure and organization of phospholipid/polysaccharide nanoparticles
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gerelli, Y; Di Bari, MT; Deriu, A; Cantu, L; Colombo, P; Como, C; Motta, S; Sonvico, F; May, R (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 20 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • \"[Gerelli, Y.; Di Bari, M. T.; Deriu, A.] Univ Parma, Dipartimento Fis, I-43100 Parma, Italy; [Gerelli, Y.; Di Bari, M. T.; Deriu, A.] Univ Parma, CNISM, I-43100 Parma, Italy; [Gerelli, Y.; Di Bari, M. T.; Deriu, A.] CNR, INFM, CRS SOFT, I-00185 Rome, Italy; [Cantu, L.] Univ Milan, LITA, Dipartimento Chim Biochim & Biotecnol Med, I-20122 Milan, Italy; [Colombo, P.; Como, C.; Motta, S.; Sonvico, F.] Univ Parma, Dipartimento Farmaceut, I-43100 Parma, Italy; [May, R.] Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France (literal)
Titolo
  • Structure and organization of phospholipid/polysaccharide nanoparticles (literal)
Abstract
  • \"In recent years nanoparticles and microparticles composed of polymeric or lipid material have been proposed as drug carriers for improving the efficacy of encapsulated drugs. For the production of these systems different materials have been proposed, among them phospholipids and polysaccharides due to their biocompatibility, biodegradability, low cost and safety. We report here a morphological and structural investigation, performed using cryo-TEM, static light scattering and small angle neutron and x-ray scattering, on phospholipid/saccharide nanoparticles loaded with a lipophilic positively charged drug (tamoxifen citrate) used in breast cancer therapy. The lipid component was soybean lecithin; the saccharide one was chitosan that usually acts as an outer coating increasing vesicle stability. The microscopy and scattering data indicate the presence of two distinct nanoparticle families: uni-lamellar vesicles with average radius 90 angstrom and multi-lamellar vesicles with average radius 440 angstrom. In both families the inner core is occupied by the solvent. The presence of tamoxifen gives rise to a multi-lamellar structure of the lipid outer shell. It also induces a positive surface charge into the vesicles, repelling the positively charged chitosan molecules which therefore do not take part in nanoparticle formation.\" (literal)
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