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Magnetic and relaxometric properties of polyethylenimine-coated superparamagnetic MRI contrast agents (Articolo in rivista)

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Magnetic and relaxometric properties of polyethylenimine-coated superparamagnetic MRI contrast agents (Articolo in rivista) (literal)

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Corti, M; Lascialfari, A; Marinone, M; Masotti, A; Micotti, E; Orsini, F; Ortaggi, G; Poletti, G; Innocenti, C; Sangregorio, C (2008)
Magnetic and relaxometric properties of polyethylenimine-coated superparamagnetic MRI contrast agents
in Journal of magnetism and magnetic materials; Elsevier Science Publishers, Amsterdam (Paesi Bassi)
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Corti, M; Lascialfari, A; Marinone, M; Masotti, A; Micotti, E; Orsini, F; Ortaggi, G; Poletti, G; Innocenti, C; Sangregorio, C (literal)

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\"[Corti, M.; Lascialfari, A.; Micotti, E.] Univ Pavia, Dipartimento Fis A Volta, Unita CNR INFM, I-27100 Pavia, Italy; [Corti, M.; Lascialfari, A.; Micotti, E.] CNISM, I-27100 Pavia, Italy; [Lascialfari, A.; Marinone, M.; Orsini, F.; Poletti, G.] Univ Milan, Ist Fis Gen & Chim Biol, I-20134 Milan, Italy; [Lascialfari, A.; Marinone, M.; Orsini, F.; Poletti, G.] S3 CNR INFM, I-41100 Modena, Italy; [Masotti, A.; Ortaggi, G.; Innocenti, C.] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; [Sangregorio, C.] Univ Florence, Dipartimento Chim, I-50019 Florence, Italy; [Sangregorio, C.] Univ Florence, INSTM, I-50019 Florence, Italy (literal)

Titolo

Magnetic and relaxometric properties of polyethylenimine-coated superparamagnetic MRI contrast agents (literal)

Abstract

Novel systems to be employed as superparamagnetic contrast agents (CA) for magnetic resonance imaging (MRI) have been synthesized. These compounds are composed of an iron oxide magnetic core coated by polyethylenimine (PEI) or carboxylated polyethylenimine (PEI-COOH). The aim of the present work was to prepare and study new nanostructured systems (with better or at least comparable relaxivities, R-1 and R-2, with respect to the commercial ones) with controlled, almost monodisperse average dimensions and shape, as candidates for molecular targeting. By means of atomic force microscopy (AFM) measurements we determined the average diameter, of the order of 200 nm, and the shape of the particles. The superparamagnetic behavior was assessed by SQUID measurements. From X-ray data the estimated average diameters of the magnetic cores were found to be similar to 5.8nm for PEI-COOH60 and similar to 20nm for the compound named PEI25. By NMR-dispersion (NMRD), we found that PEI-COOH60 presents R-1 and R-2 relaxivities slightly lower than Endorem(R). The experimental results suggest that these novel compounds can be used as MRI CA. (C) 2008 Elsevier B.V. All rights reserved. (literal)

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