http://www.cnr.it/ontology/cnr/individuo/prodotto/ID34003
Control of cell adhesion and spreading by spatial microarranged PEO-like and pdAA domains (Articolo in rivista)
- Type
- Label
- Control of cell adhesion and spreading by spatial microarranged PEO-like and pdAA domains (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.surfcoat.2005.02.063 (literal)
- Alternative label
E. Sardella1,2; R. Gristina2; G. Ceccone3; D. Gilliland3; A. Papadopoulou-Bouraoui3; F. Rossi3; G.S. Senesi2; L. Detomaso1; P. Favia1; R. d'Agostino1 (2005)
Control of cell adhesion and spreading by spatial microarranged PEO-like and pdAA domains
in Surface & coatings technology; Elsevier B.V., Amsterdam (Belgio)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. Sardella1,2; R. Gristina2; G. Ceccone3; D. Gilliland3; A. Papadopoulou-Bouraoui3; F. Rossi3; G.S. Senesi2; L. Detomaso1; P. Favia1; R. d'Agostino1 (literal)
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- ISI Web of Science (WOS) (literal)
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- 1 - Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy
2 - Institute of Inorganic Methodologies and Plasmas-Bari, CNR, Via Orabona 4, 70126, Bari, Italy
3 - Joint Research Centre, Institute of Health and Consumer protection, Biomedical Materials and System Unit, Via E. Fermi 1, Ispra (VA), Italy (literal)
- Titolo
- Control of cell adhesion and spreading by spatial microarranged PEO-like and pdAA domains (literal)
- Abstract
- Microstructured surfaces are widely used in cell culture experiments to understand the fundamentals of cell-material interactions by a spatial control of cell adhesion and spreading. Recent studies have documented that both substrate chemistry and topography are tightly correlated to cell behaviours. For this reason a wide range of techniques have been explored for obtaining in a simple and cheap way reproducible patterned substrates. This paper describes how to produce micropatterned substrates by a spatial microarrangment of chemically different domains, produced by plasma deposition. Cell-repulsive zones, obtained by plasma deposited PolyethyleneOxide-like (PEO-like) coating, were alternated with cell-adhesive tracks, namely plasma deposited Acrylic Acid (pdAA) films. Time lapse experiments demonstrated that such patterns, suitable to exert chemical and topographical constraints for cell-adhesion, can also support migration of cells inside the produced pattern. (literal)
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