http://www.cnr.it/ontology/cnr/individuo/prodotto/ID329089

Brain 18F-DOPA PET and cognition in de novo Parkinson's disease. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Brain 18F-DOPA PET and cognition in de novo Parkinson's disease. (Articolo in rivista) (literal)

Anno

2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00259-015-3039-0) (literal)

Alternative label

Agnese Picco 1*, Silvia Morbelli 2*, Arnoldo Piccardo 3, Dario Arnaldi 1, Nicola Girtler 1,4, Andrea Brugnolo 1, Irene Bossert 2, Lucio Marinelli 5, Antonio Castaldi 6, Fabrizio De Carli 7, Claudio Campus 8, Giovanni Abbruzzese 5, Flavio Nobili 1 (2015)
Brain 18F-DOPA PET and cognition in de novo Parkinson's disease.
in European journal of nuclear medicine and molecular imaging (Internet)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Agnese Picco 1*, Silvia Morbelli 2*, Arnoldo Piccardo 3, Dario Arnaldi 1, Nicola Girtler 1,4, Andrea Brugnolo 1, Irene Bossert 2, Lucio Marinelli 5, Antonio Castaldi 6, Fabrizio De Carli 7, Claudio Campus 8, Giovanni Abbruzzese 5, Flavio Nobili 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

Pubblicato on-line: 28 Marzo 2015 (literal)

Rivista

European journal of nuclear medicine and molecular imaging (Rivista)

Note

PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

* Contributed equally to this work. 1. Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy 2. Nuclear Medicine, Department of Health Sciences (DISSAL), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy 3. Nuclear Medicine, Department of Imaging Diagnostics, Ospedali Galliera, Genoa, Italy 4. Clinical Psychology and Psychotherapy Unit, IRCCS San Martino-IST, Genoa, Italy 5. Neurological Rehabilitation, Department of Neuroscience (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST,Genoa, Italy 6. Radiology, Department of Imaging Diagnostics, Ospedali Galliera, Genoa, Italy 7. Institute of Bioimaging and Molecular Physiology, Consiglio Nazionale delle Ricerche (CNR), Genoa, Italy 8. Istituto Italiano di Tecnologia, Genoa, Italy (literal)

Titolo

Brain 18F-DOPA PET and cognition in de novo Parkinson's disease. (literal)

Abstract

PURPOSE: The role of mesocortical dopaminergic pathways in the cognitive function of patients with early Parkinson's disease (PD) needs to be further clarified. METHODS: The study groups comprised 15 drug-naive patients with de novo PD and 10 patients with essential tremor (controls) who underwent 18F-DOPA PET (static acquisition, normalization on mean cerebellar counts) and an extended neuropsychological test battery. Factor analysis with varimax rotation was applied to the neuropsychological test scores, to yield five factors from 16 original scores, which explained 82 % of the total variance. Correlations between cognitive factors and 18F-DOPA uptake were assessed with SPM8, taking age and gender as nuisance variables. RESULTS: 18F-DOPA uptake was significantly lower in PD patients than in controls in the bilateral striatum, mainly in the more affected (right) hemisphere, and in a small right temporal region. Significant positive correlations were found only in PD patients between the executive factor and 18F-DOPA uptake in the bilateral anterior cingulate cortex (ACC) and the middle frontal gyrus, between the verbal fluency factor and 18F-DOPA uptake in left BA 46 and the bilateral striatum, and between the visuospatial factor and 18F-DOPA uptake in the left ACC and bilateral striatum. No correlations were found between 18F-DOPA uptake and either the verbal memory factor or the abstraction-working memory factor. CONCLUSION: These data clarify the role of the mesocortical dopaminergic pathways in cognitive function in early PD, highlighting the medial frontal lobe, anterior cingulate, and left BA 46 as the main sites of cortical correlation with executive and language functions. (literal)

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