Selective Dicer Suppression in the Kidney Alters gsk3?/?-Catenin Pathways Promoting a Glomerulocystic Disease. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Selective Dicer Suppression in the Kidney Alters gsk3?/?-Catenin Pathways Promoting a Glomerulocystic Disease. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0119142 (literal)

Alternative label

• Iervolino A1, Trepiccione F2, Petrillo F3, Spagnuolo M4, Scarfò M1, Frezzetti D1, De Vita G5, De Felice M6, Capasso G2. (2015)
  Selective Dicer Suppression in the Kidney Alters gsk3?/?-Catenin Pathways Promoting a Glomerulocystic Disease.
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Iervolino A1, Trepiccione F2, Petrillo F3, Spagnuolo M4, Scarfò M1, Frezzetti D1, De Vita G5, De Felice M6, Capasso G2. (literal)

Pagina inizio

• e0119142 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119142 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 10 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Biogem, Istituto di Ricerche Genetiche Gaetano Salvatore, Ariano Irpino, Italy. 2Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy. 3Biogem, Istituto di Ricerche Genetiche Gaetano Salvatore, Ariano Irpino, Italy; Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy. 4Department of Cardio-Thoracic and Respiratory Science, Second University of Naples, Naples, Italy; Institute of Genetics and Biophysics A. Buzzati Traverso, CNR Naples, Italy. 5Department of Molecular Medicine and Medical Biotechnologies, University of Naples \"Federico II\", Naples, Italy. 6Biogem, Istituto di Ricerche Genetiche Gaetano Salvatore, Ariano Irpino, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples \"Federico II\", Naples, Italy. (literal)

Titolo

• Selective Dicer Suppression in the Kidney Alters gsk3?/?-Catenin Pathways Promoting a Glomerulocystic Disease. (literal)

Abstract

• Dicer is a crucial enzyme for the maturation of miRNAs. Mutations in the Dicer gene are highly associated with Pleuro Pulmonary Blastoma-Family Dysplasia Syndrome (PPB-FDS, OMIM 601200), recently proposed to be renamed Dicer syndrome. Aside from the pulmonary phenotype (blastoma), renal nephroma and thyroid goiter are frequently part of Dicer syndrome. To investigate the renal phenotype, conditional knockout (cKO) mice for Dicer in Pax8 expressing cells were generated. Dicer cKO mice progressively develop a glomerulocystic phenotype coupled with urinary concentration impairment, proteinuria and severe renal failure. Higher cellular turnover of the parietal cells of Bowman's capsule precedes the development of the cysts and the primary cilium progressively disappears with cyst-enlargement. Upregulation of GSK3? precedes the development of the glomerulocystic phenotype. Downregulation of ?-catenin in the renal cortex and its cytosolic removal in the cells lining the cysts may be associated with observed accumulation of GSK3?. Alterations of ?-catenin regulating pathways could promote cystic degeneration as in other models. Thus, miRNAs are fundamental in preserving renal morphology and function. Alteration of the GSK3?/?-catenin pathway could be a crucial mechanism linking miRNA dysregulation and the development of a glomerulocystic disease. (literal)

Prodotto di

• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)
• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• Manuela Spagnuolo (Unità di personale esterno)
• MARIO DE FELICE (Persona)

Incoming links:

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Ruolo del fattore di trascrizione PAX8 nella proliferazione e nella sopravvivenza cellulare (SV.P15.001.003) (Modulo)

Autore CNR di

• Manuela Spagnuolo (Unità di personale esterno)
• MARIO DE FELICE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)