http://www.cnr.it/ontology/cnr/individuo/prodotto/ID326646

Census of solo LuxR genes in prokaryotic genomes (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Census of solo LuxR genes in prokaryotic genomes (Articolo in rivista) (literal)

Anno

2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.3389/fcimb.2015.00020 (literal)

Alternative label

S. Hudaiberdiev (1), K. S. Choudhary (1), R. Vera Alvarez (2), Z. Gelencsér (2), B. Ligeti (2), D. Lamba (3), S. Pongor(1,2) (2015)
Census of solo LuxR genes in prokaryotic genomes
in Frontiers in cellular and infection microbiology; Frontiers Research Foundation, Lausanne (Swaziland)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

S. Hudaiberdiev (1), K. S. Choudhary (1), R. Vera Alvarez (2), Z. Gelencsér (2), B. Ligeti (2), D. Lamba (3), S. Pongor(1,2) (literal)

Pagina inizio

1 (literal)

Pagina fine

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://journal.frontiersin.org/article/10.3389/fcimb.2015.00020/abstract (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

5 (literal)

Rivista

Frontiers in cellular and infection microbiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

20 (literal)

Note

PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(1) Protein Structure and Bioinformatics, International Center for Genetic Engineering and Biotechnology, Trieste, Italy, (2) Faculty of Information Technology and Bionics, Pázmány Peter Catholic University, Budapest, Hungary (3) Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, U.O.S di Trieste, Area Science Park, Basovizza, Trieste, Italy (literal)

Titolo

Census of solo LuxR genes in prokaryotic genomes (literal)

Abstract

luxR genes encode transcriptional regulators that control acyl homoserine lactone-based quorum sensing (AHL QS) in Gram negative bacteria. On the bacterial chromosome, luxR genes are usually found next or near to a luxI gene encoding the AHL signal synthase. Recently, a number of luxR genes were described that have no luxI genes in their vicinity on the chromosome. These so-called solo luxR genes may either respond to internal AHL signals produced by a non-adjacent luxI in the chromosome, or can respond to exogenous signals. Here we present a survey of solo luxR genes found in complete and draft bacterial genomes in the NCBI databases using HMMs. We found that 2698 of the 3550 luxR genes found are solos, which is an unexpectedly high number even if some of the hits may be false positives. We also found that solo LuxR sequences form distinct clusters that are different from the clusters of LuxR sequences that are part of the known luxR-luxI topological arrangements. We also found a number of cases that we termed twin luxR topologies, in which two adjacent luxR genes were in tandem or divergent orientation. Many of the luxR solo clusters were devoid of the sequence motifs characteristic of AHL binding LuxR proteins so there is room to speculate that the solos may be involved in sensing hitherto unknown signals. It was noted that only some of the LuxR clades are rich in conserved cysteine residues. Molecular modeling suggests that some of the cysteines may be involved in disulfide formation, which makes us speculate that some LuxR proteins, including some of the solos may be involved in redox regulation (literal)

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