Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation (Articolo in rivista)

Type
Label
  • Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation (Articolo in rivista) (literal)
Anno
  • 1996-01-01T00:00:00+01:00 (literal)
Alternative label
  • Peverali, Fiorenzo A A; Isaksson, Anders I.; Papavassiliou, Athanasios G.; Plastina, Pierfrancesco; Staszewski, Lena M.; Mlodzik, Marek; Bohmann, Dirk (1996)
    Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation
    in EMBO journal (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Peverali, Fiorenzo A A; Isaksson, Anders I.; Papavassiliou, Athanasios G.; Plastina, Pierfrancesco; Staszewski, Lena M.; Mlodzik, Marek; Bohmann, Dirk (literal)
Pagina inizio
  • 3943 (literal)
Pagina fine
  • 3950 (literal)
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  • http://www.scopus.com/record/display.url?eid=2-s2.0-0029738257&origin=inward (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
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  • 15 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • European Molecular Biology Laboratory Heidelberg (literal)
Titolo
  • Phosphorylation of Drosophila Jun by the MAP kinase Rolled regulates photoreceptor differentiation (literal)
Abstract
  • Drosophila Jun (D-Jun) is a nuclear component of the receptor tyrosine kinase/Ras signal transduction pathway which triggers photoreceptor differentiation during eye development. Here we show that D-Jun is a substrate for the ERK-related Drosophila MAP kinase Rolled, which has previously been shown to be a part of this pathway. A D-Jun mutant that carries alanines in place of the Rolled phosphorylation sites acts as a dominant suppressor of photoreceptor cell fate if expressed in the eye imaginal disc. In contrast, a mutant in which the phosphorylation sites are replaced by phosphate-mimetic Asp residues, as well as a VP16-D-Jun fusion protein, can promote photoreceptor differentiation. These data implicate Jun phosphorylation in the choice between neuronal and non-neuronal fate during Drosophila eye development. (literal)
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