No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. (Articolo in rivista)

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  • No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/2191-219X-3-39 (literal)
Alternative label
  • Thomsen, Gerda; Knudsen, Gitte Moos; Jensen, Peter S; Ziebell, Morten; Holst, Klaus K; Asenbaum, Susanne; Booij, Jan; Darcourt, Jacques; Dickson, John C; Kapucu, Ozlem L; Nobili, Flavio; Sabri, Osama; Sera, Terez; Tatsch, Klaus; Tossici-Bolt, Livia; Laere, Koen Van; Borght, Thierry Vander; Varrone, Andrea; Pagani, Marco; Pinborg, Lars Hageman (2013)
    No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT.
    in European Journal of Nuclear Medicine and Molecular Imaging Research; Springer, Berlin Heidelberg (Germania)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Thomsen, Gerda; Knudsen, Gitte Moos; Jensen, Peter S; Ziebell, Morten; Holst, Klaus K; Asenbaum, Susanne; Booij, Jan; Darcourt, Jacques; Dickson, John C; Kapucu, Ozlem L; Nobili, Flavio; Sabri, Osama; Sera, Terez; Tatsch, Klaus; Tossici-Bolt, Livia; Laere, Koen Van; Borght, Thierry Vander; Varrone, Andrea; Pagani, Marco; Pinborg, Lars Hageman (literal)
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  • 3 (literal)
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  • 7 (literal)
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  • 1 (literal)
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  • ISI Web of Science (WOS) (literal)
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  • Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark. Department of Nuclear Medicine, Medical University of Vienna, Vienna 1090, Austria. Department of Nuclear Medicine, Academic Medical Centre University of Amsterdam, Amsterdam 1100, The Netherlands. Nuclear Medicine Department, Centre Antoine Lacassagne, University of Nice-Sophia Antipolis, Nice 06189, France. Institute of Nuclear Medicine, UCLH NHS Foundation Trust and University College, London NW12BU, UK. Department of Nuclear Medicine, Gazi University, Faculty of Medicine, Ankara 06500, Turkey. Clinical Neurophysiology Unit, Department of Neurosceince, Ophthalmology and Genetics, University of Genoa, Genoa 16132, Italy. Department of Nuclear Medicine, University of Leipzig, Leipzig 04103, Germany. Department of Nuclear Medicine and Euromedic Szeged, University of Szeged, Szeged 6720, Hungary. Department of Nuclear Medicine, Municipal Hospital of Karlsruhe Inc., Karlsruhe 76133, Germany. Department of Medical Physics and Bioengineering, University Hospital Southampton NHS Foundation Trust, Southampton SO166YD, UK. Nuclear Medicine, University Hospital and KU Leuven, Leuven 3000, Belgium. Nuclear Medicine Division, Mont-Godinne Medical Center, Université Catholique de Louvain, Louvain-la-Neuve, Yvoir 5530, Belgium. Department of Clinical Neuroscience, Karolinska University Hospital, Stockholm 17176, Sweden. Department of Nuclear Medicine, Karolinska University Hospital, Stockholm 17176, Sweden. Epilepsy Clinic 8501, Rigshospitalet and Copenhagen University Hospital, Copenhagen 2100, Denmark. Department of Biostatistics, University of Copenhagen, Copenhagen 2100, Denmark. (literal)
Titolo
  • No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT. (literal)
Abstract
  • Background: Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminergic neurotransmission and in particular in activating the striatal D2-like receptors. Molecular imaging studies of the relationship between DAT availability/dopamine synthesis capacity and active cigarette smoking have shown conflicting results. Through the collaboration between 13 SPECT centres located in 10 different European countries, a database of FP-CIT-binding in healthy controls was established. We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers. Methods: A total of 129 healthy volunteers were included. Subjects were divided into three categories according to past and present tobacco smoking: (1) non-smokers (n = 64), (2) ex-smokers (n = 39) and (3) active smokers (n = 26). For imaging of the DAT availability, we used [123I]FP-CIT (DaTSCAN) and single photon emission computed tomography (SPECT). Data were collected in collaboration between 13 SPECT centres located in 10 different European countries. The striatal measure of DAT availability was analyzed in a multiple regression model with age, SPECT centre and smoking as predictor. Results: There was no statistically significant difference in DAT availability between the groups of active smokers, ex-smokers and non-smokers (p = 0.34). Further, we could not demonstrate a significant association between striatal DAT and the number of cigarettes per day or total lifetime cigarette packages in smokers and ex-smokers. Conclusion: Our results do not support the hypothesis that large differences in striatal DAT availability are present in smokers compared to ex-smokers and healthy volunteers with no history of smoking. Keywords: Tobacco smoking, Non-smoking, SPECT, [123I]FP-CIT (DaTSCAN), Dopamine transporter (literal)
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