http://www.cnr.it/ontology/cnr/individuo/prodotto/ID323631

European multicentre database of healthy controls for [123I]FP- CIT SPECT (ENC-DAT): Age-related effects, gender differences and evaluation of different methods of analysis (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

European multicentre database of healthy controls for [123I]FP- CIT SPECT (ENC-DAT): Age-related effects, gender differences and evaluation of different methods of analysis (Articolo in rivista) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00259-012-2276-8 (literal)

Alternative label

Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Knudsen, Gitte Moos; Koulibaly, Pierre Malick; Nobili, Flavio Mariano; Pagani, Marco; Sabri, Osama; Vander Borght, Thierry M.; Van Laere, Koen Van R; Tatsch, Klaus (2013)
European multicentre database of healthy controls for [123I]FP- CIT SPECT (ENC-DAT): Age-related effects, gender differences and evaluation of different methods of analysis
in European journal of nuclear medicine and molecular imaging (Print); Springer, Berlin Heidelberg (Germania)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Knudsen, Gitte Moos; Koulibaly, Pierre Malick; Nobili, Flavio Mariano; Pagani, Marco; Sabri, Osama; Vander Borght, Thierry M.; Van Laere, Koen Van R; Tatsch, Klaus (literal)

Pagina inizio

213 (literal)

Pagina fine

227 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/record/display.url?eid=2-s2.0-84874112863&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

40 (literal)

Rivista

European journal of nuclear medicine and molecular imaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Karolinska University Hospital; UCL; Southampton University Hospitals NHS Trust; Szegedi Tudomanyegyetem; Medizinische Universitat Wien; Academic Medical Centre, University of Amsterdam; Gazi Universitesi; ABX-CRO; Kobenhavns Universitet; Universite Nice Sophia Antipolis; Universita degli Studi di Genova; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universitat Leipzig; Universite Catholique de Louvain; University Hospital Leuven; Municipal Hospital Karlsruhe Inc. (literal)

Titolo

European multicentre database of healthy controls for [123I]FP- CIT SPECT (ENC-DAT): Age-related effects, gender differences and evaluation of different methods of analysis (literal)

Abstract

Purpose Dopamine transporter (DAT) imaging with [123I] FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One critical aspect of quantification is the availability of normative data, considering possible age and gender effects on DAT availability. The aim of the European Normal Control Database of DaTSCAN (ENC-DAT) study was to generate a large database of [123I]FP-CIT SPECT scans in healthy controls. Methods SPECT data from 139 healthy controls (74 men, 65 women; age range 20-83 years, mean 53 years) acquired in 13 different centres were included. Images were reconstructed using the ordered-subset expectationmaximization algorithm without correction (NOACSC), with attenuation correction (AC), and with both attenuation and scatter correction using the triple-energy window method (ACSC). Region-of-interest analysis was performed using the BRASS software (caudate and putamen), and the Southampton method (striatum). The outcome measure was the specific binding ratio (SBR). Results A significant effect of age on SBR was found for all data. Gender had a significant effect on SBR in the caudate and putamen for the NOACSC and AC data, and only in the left caudate for the ACSC data (BRASS method). Significant effects of age and gender on striatal SBR were observed for all data analysed with the Southampton method. Overall, there was a significant age-related decline in SBR of between 4 % and 6.7 % per decade. Conclusion This study provides a large database of [123I]FP-CIT SPECT scans in healthy controls across a wide age range and with balanced gender representation. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 5.5 % per decade was found for both genders, in agreement with previous reports. The data collected in this study may serve as a reference database for nuclear medicine centres and for clinical trials using [123I]FPCIT SPECT as the imaging marker. (literal)

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