http://www.cnr.it/ontology/cnr/individuo/prodotto/ID323612

Value of semiquantitative analysis for clinical reporting of 123I-2-?-carbomethoxy-3?-(4-iodophenyl)-N-(3-fluoropropyl) nortropane SPECT studies (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Value of semiquantitative analysis for clinical reporting of 123I-2-?-carbomethoxy-3?-(4-iodophenyl)-N-(3-fluoropropyl) nortropane SPECT studies (Articolo in rivista) (literal)

Anno

2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.2967/jnumed.112.110106 (literal)

Alternative label

Söderlund, Therese A.; Dickson, John Caddell; Prvulovich, Elizabeth M.; Ben-Haim, Simona A.; Kemp, Paul M.; Booij, Jan; Nobili, Flavio Mariano; Thomsen, Gerda; Sabri, Osama; Koulibaly, Pierre Malik; Akdemir, Özgür Ümit; Pagani, Marco; Van Laere, Koen Van R; Asenbaum-Nan, Susanne; George, Jean Claude; Séra, Teréz; Tatsch, Klaus; Bomanji, Jamshed B. (2013)
Value of semiquantitative analysis for clinical reporting of 123I-2-?-carbomethoxy-3?-(4-iodophenyl)-N-(3-fluoropropyl) nortropane SPECT studies
in The Journal of nuclear medicine (1978); Society of Nuclear Medicine, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Söderlund, Therese A.; Dickson, John Caddell; Prvulovich, Elizabeth M.; Ben-Haim, Simona A.; Kemp, Paul M.; Booij, Jan; Nobili, Flavio Mariano; Thomsen, Gerda; Sabri, Osama; Koulibaly, Pierre Malik; Akdemir, Özgür Ümit; Pagani, Marco; Van Laere, Koen Van R; Asenbaum-Nan, Susanne; George, Jean Claude; Séra, Teréz; Tatsch, Klaus; Bomanji, Jamshed B. (literal)

Pagina inizio

714 (literal)

Pagina fine

722 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/record/display.url?eid=2-s2.0-84877116997&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

54 (literal)

Rivista

?The ?Journal of nuclear medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

5 (literal)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

UCL; Southampton University Hospitals NHS Trust; Academic Medical Centre, University of Amsterdam; Universita degli Studi di Genova; Kobenhavns Universitet; Universitat Leipzig; Universite Nice Sophia Antipolis; Gazi University, Faculty of Medicine; Karolinska University Hospital; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; University Hospital Leuven; Medizinische Universitat Wien; Universite Catholique de Louvain; Szegedi Tudomanyegyetem; Karlsruhe Hospital; Ludwig-Maximilians-Universitat Munchen (literal)

Titolo

Value of semiquantitative analysis for clinical reporting of 123I-2-?-carbomethoxy-3?-(4-iodophenyl)-N-(3-fluoropropyl) nortropane SPECT studies (literal)

Abstract

Clinical 123I-2-b-carbomethoxy-3b-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) SPECT studies are commonly performed and reported using visual evaluation of tracer binding, an inherently subjective method. Increased objectivity can potentially be obtained using semiquantitative analysis. In this study, we assessed whether semiquantitative analysis of 123I-FP-CIT tracer binding created more reproducible clinical reporting. A secondary aim was to determine in what form semiquantitative data should be provided to the reporter. Methods: Fifty-four patients referred for the assessment of nigrostriatal dopaminergic degeneration were scanned using SPECT/CT, followed by semiquantitative analysis calculating striatal binding ratios (SBRs) and caudate-to-putamen ratios (CPRs). Normal reference values were obtained using 131 healthy controls enrolled on a multicenter initiative backed by the European Association of Nuclear Medicine. A purely quantitative evaluation was first performed, with each striatum scored as normal or abnormal according to reference values. Three experienced nuclear medicine physicians then scored each striatum as normal or abnormal, also indicating cases perceived as difficult, using visual evaluation, visual evaluation in combination with SBR data, and visual evaluation in combination with SBR and CPR data. Intra- and interobserver agreement and agreement between observers and the purely quantitative evaluation were assessed using k-statistics. The agreement between scan interpretation and clinical diagnosis was assessed for patients with a postscan clinical diagnosis available (n 5 35). Results: The physicians showed consistent reporting, with a good intraobserver agreement obtained for the visual interpretation (mean k 6 SD, 0.95 6 0.029). Although visual interpretation of tracer binding gave good interobserver agreement (0.80 6 0.045), this was improved as SBRs (0.86 6 0.070) and CPRs (0.95 6 0.040) were provided. The number of striata perceived as difficult to interpret decreased as semiquantitative data were provided (30 for the visual interpretation; 0 as SBR and CPR values were given). The agreement between physicians' interpretations and the purely quantitative evaluation showed that readers used the semiquantitative data to different extents, with a more experienced reader relying less on the semiquantitative data. Good agreement between scan interpretation and clinical diagnosis was seen. Conclusion: A combined approach of visual assessment and semiquantitative analysis of tracer binding created more reproducible clinical reporting of 123I-FP-CIT SPECT studies. Physicians should have access to both SBR and CPR data to minimize interobserver variability. (literal)

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