http://www.cnr.it/ontology/cnr/individuo/prodotto/ID323573

Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00259-014-2785-8 (literal)

Alternative label

Koch, Walter H.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter P.; Diemling, Markus; Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Ziebell, Morten; Darcourt, Jacques; Nobili, Flavio Mariano; Pagani, Marco; Hesse, Swen; Vander Borght, Thierry M.; Van Laere, Koen Van R; Tatsch, Klaus; La Fougère, Christian (2014)
Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls
in European journal of nuclear medicine and molecular imaging (Print); Springer, Berlin Heidelberg (Germania)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Koch, Walter H.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter P.; Diemling, Markus; Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Ziebell, Morten; Darcourt, Jacques; Nobili, Flavio Mariano; Pagani, Marco; Hesse, Swen; Vander Borght, Thierry M.; Van Laere, Koen Van R; Tatsch, Klaus; La Fougère, Christian (literal)

Pagina inizio

1938 (literal)

Pagina fine

1946 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/record/display.url?eid=2-s2.0-84901552024&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

41 (literal)

Rivista

European journal of nuclear medicine and molecular imaging (Rivista)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Ludwig-Maximilians-Universitat Munchen; Hermes Medical Solutions; Karolinska University Hospital; NHS Foundation Trust; Southampton University Hospitals NHS Trust; Szegedi Tudomanyegyetem; Medizinische Universitat Wien; Academic Medical Centre, University of Amsterdam; Gazi Universitesi; ABX-CRO; Kobenhavns Universitet; Universite Nice Sophia Antipolis; Universita degli Studi di Genova; Istituto Di Scienze E Tecnologie Della Cognizione, Rome; Universitat Leipzig; Universite Catholique de Louvain; Katholieke Universiteit Leuven; Stadtischen Klinikum Karlsruhe; Universitat Tubingen (literal)

Titolo

Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls (literal)

Abstract

Purpose Apart from binding to the dopamine transporter (DAT), [123I]FP-CITshows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls. Methods SPECT data from 103 healthy controls with welldefined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding. Results Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2±1.3 % for the thalamus and 6.8±2.9 % for the pons was shown. Conclusion The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [123I]FPCIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [123I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors. (literal)

Editore