Vitamin D deficiency predicts cognitive decline in older men and women The Pro.VA Study (Articolo in rivista)

Type
Label
  • Vitamin D deficiency predicts cognitive decline in older men and women The Pro.VA Study (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1212/WNL.0000000000001080 (literal)
Alternative label
  • Toffanello, Elena D.; Coin, Alessandra; Perissinotto, Egle; Zambon, Sabina; Sarti, Silvia; Veronese, Nicola; De Rui, Marina; Bolzetta, Francesco; Corti, Maria-Chiara; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe (2014)
    Vitamin D deficiency predicts cognitive decline in older men and women The Pro.VA Study
    in Neurology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Toffanello, Elena D.; Coin, Alessandra; Perissinotto, Egle; Zambon, Sabina; Sarti, Silvia; Veronese, Nicola; De Rui, Marina; Bolzetta, Francesco; Corti, Maria-Chiara; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe (literal)
Pagina inizio
  • 2292 (literal)
Pagina fine
  • 2298 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/25378671 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 83 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 24 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Padua; University of Padua; University of Padua; Consiglio Nazionale delle Ricerche (CNR); Azienda Unita Locale Socio Sanit 16 (literal)
Titolo
  • Vitamin D deficiency predicts cognitive decline in older men and women The Pro.VA Study (literal)
Abstract
  • Objective:To test the hypothesis that hypovitaminosis D is associated with a higher risk of cognitive decline over a 4.4-year follow-up in a large sample of older adults.Methods:This research was part of the Progetto Veneto Anziani (Pro.V.A.), an Italian population-based cohort study of 1,927 elderly subjects. Serum 25-hydroxyvitamin D (25OHD) levels were measured at the baseline. Global cognitive function was measured with the Mini-Mental State Examination (MMSE); scores lower than 24 were indicative of cognitive dysfunction, and a decline of 3 or more points on the MMSE over the follow-up was considered as clinically significant. Analyses were adjusted for relevant confounders, including health and performance status.Results:Participants with 25OHD deficiency (<50 nmol/L) or insufficiency (50-75 nmol/L) were more likely to have declining MMSE scores during the follow-up than those who were 25OHD sufficient (75 nmol/L). Among participants cognitively intact (baseline MMSE scores 24 and without diagnosis of dementia), the multivariate adjusted relative risk (95% confidence interval [CI]) of the onset of cognitive dysfunction was 1.36 (95% CI: 1.04-1.80; p = 0.02) for those with vitamin D deficiency and 1.29 (95% CI: 1.00-1.76; p = 0.05) for those with vitamin D insufficiency by comparison with individuals with normal 25OHD levels.Conclusion:The results of our study support an independent association between low 25OHD levels and cognitive decline in elderly individuals. In cognitively intact elderly subjects, 25OHD levels below 75 nmol/L are already predictive of global cognitive dysfunction at 4.4 years. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it