MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.molcel.2014.01.013 (literal)

Alternative label

• Patron, Maria; Checchetto, Vanessa; Raffaello, Anna; Teardo, Enrico; Reane, Denis Vecellio; Mantoan, Maura; Granatiero, Veronica; Szabo, Ildiko; De Stefani, Diego; Rizzuto, Rosario (2014)
  MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity
  in Molecular cell
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Patron, Maria; Checchetto, Vanessa; Raffaello, Anna; Teardo, Enrico; Reane, Denis Vecellio; Mantoan, Maura; Granatiero, Veronica; Szabo, Ildiko; De Stefani, Diego; Rizzuto, Rosario (literal)

Pagina inizio

• 726 (literal)

Pagina fine

• 737 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/24560927 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 53 (literal)

Rivista

• Molecular cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1, 3, 5, 6, 7, 9, 10: Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58, 35131 Padova, Italy / CNR Neuroscience Institute, Via Ugo Bassi 58, 35131 Padova, Italy; 2, 4, 8: Department of Biology, University of Padova, Via Ugo Bassi 58, 35131 Padova, Italy (literal)

Titolo

• MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity (literal)

Abstract

• Mitochondrial calcium accumulation was recently shown to depend on a complex composed of an inner-membrane channel (MCU and MCUb) and regulatory subunits (MICU1, MCUR1, and EMRE). A fundamental property of MCU is low activity at resting cytosolic Ca2+ concentrations, preventing deleterious Ca2+ cycling and organelle overload. Here we demonstrate that these properties are ensured by a regulatory heterodimer composed of two proteins with opposite effects, MICU1 and MICU2, which, both in purified lipid bilayers and in intact cells, stimulate and inhibit MCU activity, respectively. Both MICU1 and MICU2 are regulated by calcium through their EF-hand domains, thus accounting for the sigmoidal response of MCU to [Ca2+] in situ and allowing tight physiological control. At low [Ca2+], the dominant effect of MICU2 largely shuts down MCU activity; at higher [Ca2+], the stimulatory effect of MICU1 allows the prompt response of mitochondria to Ca2+ signals generated in the cytoplasm. (literal)

Prodotto di

• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)
• Institute of neuroscience (IN) (Istituto)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular cell (Rivista)

Autore CNR di

• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID24696