Toll-like receptors hit calcium (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Toll-like receptors hit calcium (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/embr.201438685 (literal)

Alternative label

• de Bernard, Marina; Rizzuto, Rosario (2014)
  Toll-like receptors hit calcium
  in EMBO reports (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• de Bernard, Marina; Rizzuto, Rosario (literal)

Pagina inizio

• 468 (literal)

Pagina fine

• 469 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/24692506 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• EMBO reports (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Padua; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• Toll-like receptors hit calcium (literal)

Abstract

• Mitochondrial Ca2+ uptake is a multifarious signal that controls both the activity of matrix dehydrogenases and the sensitivity to apoptotic and necrotic challenges. Recent evidence indicates that mitochondria also play a role in triggering inflammation, as mitochondrial DNA, when released by the cell, is an important damage-associated molecular pattern (DAMP). Now, Toll-like receptors (TLRs) are shown to close the loop, by affecting in turn mitochondrial activity. Two studies by Shintani and colleagues, one in this issue of EMBO reports, identify a new TLR transduction mechanism that impinges directly on mitochondrial function. Upon binding of CpG oligodeoxynucleotides, TLR9which in non-immune cells is retained in the ERinhibits SERCA2, thus reducing Ca2+ transfer to the mitochondria and aerobic metabolism. (literal)

Prodotto di

• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)
• Institute of neuroscience (IN) (Istituto)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO reports (Rivista)

Autore CNR di

• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID24696