Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity (Articolo in rivista)

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  • Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.4161/auto.32154 (literal)
Alternative label
  • Lo Verso, Francesca; Carnio, Silvia; Vainshtein, Anna; Sandri, Marco (2014)
    Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity
    in Autophagy
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lo Verso, Francesca; Carnio, Silvia; Vainshtein, Anna; Sandri, Marco (literal)
Pagina inizio
  • 1883 (literal)
Pagina fine
  • 1894 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/25483961 (literal)
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  • 10 (literal)
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  • 12 (literal)
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  • 11 (literal)
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  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1: Dulbecco Telethon Institute; Venetian Institute of Molecular Medicine; Padova, Italy / Department of Biomedical Sciences; University of Padova; Padova, Italy; 2: Dulbecco Telethon Institute; Venetian Institute of Molecular Medicine; Padova, Italy; 3: School of Kinesiology and Health Science and the Muscle Health Research Center; York University; Toronto, Canada; 4: Dulbecco Telethon Institute; Venetian Institute of Molecular Medicine; Padova, Italy / Department of Biomedical Sciences; University of Padova; Padova, Italy / Neuroscience Institute; Consiglio Nazionale delle Ricerche; Padova, Italy / Telethon Institute of Genetics and Medicine (TIGEM); Napoli, Italy (literal)
Titolo
  • Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity (literal)
Abstract
  • Physical activity has been recently documented to play a fundamental physiological role in the regulation of autophagy in several tissues. It has also been reported that autophagy is required for exercise itself and for training-induced adaptations in glucose homeostasis. These autophagy-mediated metabolic improvements are thought to be largely dependent on the activation of the metabolic sensor PRKAA1/AMPK. However, it is unknown whether these important benefits stem from systemic adaptations or are due solely to alterations in skeletal muscle metabolism. To address this we utilized inducible, muscle-specific, atg7 knockout mice that we have recently generated. Our findings indicate that acute inhibition of autophagy in skeletal muscle just prior to exercise does not have an impact on physical performance, PRKAA1 activation, or glucose homeostasis. However, we reveal that autophagy is critical for the preservation of mitochondrial function during damaging muscle contraction. This effect appears to be gender specific affecting primarily females. We also establish that basal oxidative stress plays a crucial role in mitochondrial maintenance during normal physical activity. Therefore, autophagy is an adaptive response to exercise that ensures effective mitochondrial quality control during damaging physical activity. (literal)
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