The mitochondrial permeability transition pore and its adaptive responses in tumor cells (Articolo in rivista)

Type
Label
  • The mitochondrial permeability transition pore and its adaptive responses in tumor cells (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ceca.2014.10.003 (literal)
Alternative label
  • Rasola, Andrea; Bernardi, Paolo (2014)
    The mitochondrial permeability transition pore and its adaptive responses in tumor cells
    in Cell calcium (Edinburgh)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rasola, Andrea; Bernardi, Paolo (literal)
Pagina inizio
  • 437 (literal)
Pagina fine
  • 445 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0143416014001584 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 56 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WoS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy (literal)
Titolo
  • The mitochondrial permeability transition pore and its adaptive responses in tumor cells (literal)
Abstract
  • This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) - a key effector in the mitochondrial pathways to cell death - and on the adaptive responses of tumor cells that desensitize the PTP to Ca2+ and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F-ATP synthase; and the definition of the Ca2+- and ROS-dependent signaling pathways affecting the transition of the F-ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells. (C) 2014 The Authors. Published by Elsevier Ltd. (literal)
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