Epidemiology of hypospadias in Europe: a registry-based study (Articolo in rivista)

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  • Epidemiology of hypospadias in Europe: a registry-based study (Articolo in rivista) (literal)
Anno
  • 2015-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00345-015-1507-6 (literal)
Alternative label
  • Jorieke E. H. Bergman · Maria Loane · Martine Vrijheid · Anna Pierini · Rien J. M. Nijman · Marie-Claude Addor · Ingeborg Barisic · Judit Béres · Paula Braz · Judith Budd · Virginia Delaney · Miriam Gatt · Babak Khoshnood · Kari Klungsøyr · Carmen Martos · Carmel Mullaney · Vera Nelen · Amanda J. Neville · Mary O'Mahony · Annette Queisser-Luft · Hanitra Randrianaivo · Anke Rissmann · Catherine Rounding · David Tucker · Diana Wellesley · Natalya Zymak-Zakutnia · Marian K. Bakker · Hermien E. K. de Walle (2015)
    Epidemiology of hypospadias in Europe: a registry-based study
    in World journal of urology (Print); Springer, Berlin Heidelberg (Germania)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Jorieke E. H. Bergman · Maria Loane · Martine Vrijheid · Anna Pierini · Rien J. M. Nijman · Marie-Claude Addor · Ingeborg Barisic · Judit Béres · Paula Braz · Judith Budd · Virginia Delaney · Miriam Gatt · Babak Khoshnood · Kari Klungsøyr · Carmen Martos · Carmel Mullaney · Vera Nelen · Amanda J. Neville · Mary O'Mahony · Annette Queisser-Luft · Hanitra Randrianaivo · Anke Rissmann · Catherine Rounding · David Tucker · Diana Wellesley · Natalya Zymak-Zakutnia · Marian K. Bakker · Hermien E. K. de Walle (literal)
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  • 1 (literal)
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  • 9 (literal)
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  • http://link.springer.com/article/10.1007%2Fs00345-015-1507-6#page-1 (literal)
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  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • J. E. H. Bergman (*) · M. K. Bakker · H. E. K. de Walle Department of Genetics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands e-mail: j.e.h.van.kammen@umcg.nl M. Loane EUROCAT Central Registry, Centre for Maternal, Fetal, and Infant Research, Institute of Nursing Research, University of Ulster, Northern Ireland, UK M. Vrijheid CREAL - Centre for Research in Environmental Epidemiology, Barcelona, Spain M. Vrijheid Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain A. Pierini CNR Institute of Clinical Physiology, Pisa, Italy R. J. M. Nijman Department of Urology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands M.-C. Addor Division of Medical Genetics, Lausanne, Switzerland I. Barisic Children's Hospital Zagreb, Medical School University of Zagreb, Zagreb, Croatia J. Béres Department of Hungarian Congenital Abnormality Registry and Surveillance, National Institute for Health Development, Budapest, Hungary P. Braz Department of Epidemiology, National Institute of Health, Lisbon, Portugal J. Budd Department of Health Sciences, University of Leicester, Leicester, UK V. Delaney Health Information Unit, Dr Steevens Hospital, Dublin, Ireland M. Gatt Department of Health Information and Research, Gardamangia, Malta B. Khoshnood INSERM U953, Paris, France (literal)
Titolo
  • Epidemiology of hypospadias in Europe: a registry-based study (literal)
Abstract
  • Background Hypospadias is a common congenital malformation. The prevalence of hypospadias has a large geographical variation, and recent studies have reported both increasing and decreasing temporal trends. It is unclear whether hypospadias prevalence is associated with maternal age. Aim To analyze the prevalence and trends of total hypospadias, isolated hypospadias, hypospadias with multiple congenital anomalies, hypospadias with a known cause, and hypospadias severity subtypes in Europe over a 10-year period and to investigate whether maternal age is associated with hypospadias. Methods We included all children with hypospadias born from 2001 to 2010 who were registered in 23 EUROCAT registries. Information on the total number of births and maternal age distribution for the registry population was also provided. We analyzed the total prevalence of hypospadias and relative risks by maternal age. Results From 2001 to 2010, 10,929 hypospadias cases were registered in 5,871,855 births, yielding a total prevalence of 18.61 per 10,000 births. Prevalence varied considerably between different registries, probably due to differences in ascertainment of hypospadias cases. No significant temporal trends were observed with the exceptions of an increasing trend for anterior and posterior hypospadias and a decreasing trend for unspecified hypospadias. After adjusting for registry effects, maternal age was not significantly associated with hypospadias. Conclusions Total hypospadias prevalence was stable in 23 EUROCAT registries from 2001 to 2010 and was not significantly influenced by maternal age. (literal)
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