A Multi-component Fiber-reinforced PHEMA-based Hydrogel/HAPEX™ Device for Customized Intervertebral Disc Prosthesis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A Multi-component Fiber-reinforced PHEMA-based Hydrogel/HAPEX™ Device for Customized Intervertebral Disc Prosthesis (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1177/0885328209360933v1 (literal)

Alternative label

• Gloria A. *; Causa F. **; De Santis R. *; Tanner K.E. ***, Ambrosio L.* (2010)
  A Multi-component Fiber-reinforced PHEMA-based Hydrogel/HAPEX™ Device for Customized Intervertebral Disc Prosthesis
  in Journal of biomaterials applications
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gloria A. *; Causa F. **; De Santis R. *; Tanner K.E. ***, Ambrosio L.* (literal)

Rivista

• Journal of biomaterials applications (Rivista)

Note

• ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• *Institute of Composite and Biomedical Materials, National Research Council ** Department of Experimental and Clinical Medicine, University of Magna Graecia *** Departments of Mechanical and of Civil Engineering, University of Glasgow, (literal)

Titolo

• A Multi-component Fiber-reinforced PHEMA-based Hydrogel/HAPEX™ Device for Customized Intervertebral Disc Prosthesis (literal)

Abstract

• Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide. Disc arthroplasty may be considered the future ''gold standard'' of back pain treatment, even if problems related to available disc prostheses are considered. Hence, the aim of the present study was to improve the artificial disc technology by proposing the engineering of a pilot-scale device production process for a total multi-component intervertebral disc prosthesis. The device is made up of a poly(2-hydroxyethyl methacrylate)/poly(methyl methacrylate) (PHEMA/PMMA) (80/20 w/w) semi-interpenetrating polymer network (s-IPN) composite hydrogel reinforced with poly(ethylene terephthalate) (PET) fibers as annulus/nucleus substitute, and two hydroxyapatite-reinforced polyethylene composite (HAPEX(TM)) endplates in order to anchor the multi-component device to the vertebral bodies. Static and dynamic-mechanical characterization show appropriate mechanical behavior. An example of engineering of a suitable pilot-scale device production process is also proposed in order to manufacture custom made implants. (literal)

Prodotto di

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR

• LUIGI AMBROSIO (Unità di personale interno)
• ANTONIO GLORIA (Unità di personale interno)
• ROBERTO DE SANTIS (Unità di personale interno)

Incoming links:

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR di

• ROBERTO DE SANTIS (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)
• ANTONIO GLORIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of biomaterials applications (Rivista)