http://www.cnr.it/ontology/cnr/individuo/prodotto/ID320543
Metabolic fuelling of proper T cell functions (Articolo in rivista)
- Type
- Label
- Metabolic fuelling of proper T cell functions (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.imlet.2013.12.012 (literal)
- Alternative label
Matarese, Giuseppe; Colamatteo, Alessandra; De Rosa, Veronica (2014)
Metabolic fuelling of proper T cell functions
in Immunology letters
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Matarese, Giuseppe; Colamatteo, Alessandra; De Rosa, Veronica (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Salerno; IRCCS MultiMed; IRCCS Fdn Santa Lucia; Consiglio Nazl Ric IEOS CNR (literal)
- Titolo
- Metabolic fuelling of proper T cell functions (literal)
- Abstract
- The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function. (C) 2013 Elsevier B.V. All rights reserved. (literal)
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