Polylactic acid fibre reinforced polycaprolactone scaffolds for bone tissue engineering (Articolo in rivista)

Type
Label
  • Polylactic acid fibre reinforced polycaprolactone scaffolds for bone tissue engineering (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Guarino V.; Causa F.;Taddei P.; Di Foggia M.; Ciapetti G.; Martini D.; Fagnano C.; Baldini N.; Ambrosio L; (2008)
    Polylactic acid fibre reinforced polycaprolactone scaffolds for bone tissue engineering
    in Biomaterials
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Guarino V.; Causa F.;Taddei P.; Di Foggia M.; Ciapetti G.; Martini D.; Fagnano C.; Baldini N.; Ambrosio L; (literal)
Pagina inizio
  • 3101 (literal)
Pagina fine
  • 3109 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 28 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Composite and Biomedical Materials (IMCB-CNR), P.le Tecchio 80, 80125 Naples, Italy Department of Experimental and Clinical Medicine, University of Magna Graecia, Germaneto, 88100 Catanzaro, Italy Department of Biochemsitry ‘‘G. Moruzzi’’, Alma Mater Studiorum, University of Bologna, Via Belmeloro 8/2, 40126 Bologna, Italy Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy Department of Human Anatomy, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy (literal)
Titolo
  • Polylactic acid fibre reinforced polycaprolactone scaffolds for bone tissue engineering (literal)
Abstract
  • The employment of composite scaffolds with a well-organized architecture and multi-scale porosity certainly represents a valuable approach for achieving a tissue engineered construct to reproduce the middle and long-term behaviour of hierarchically complex tissues such as spongy bone. In this paper, fibre-reinforced composites scaffold for bone tissue engineering applications is described. These are composed of poly-L-lactide acid (PLLA) fibres embedded in a porous poly(3-caprolactone) matrix, and were obtained by synergistic use of phase inversion/particulate leaching technique and filament winding technology. Porosity degree as high as 79.7% was achieved, the bimodal pore size distribution showing peaks at ca 10 and 200 mm diameter, respectively, accounting for 53.7% and 46.3% of the total porosity. In vitro degradation was carried out in PBS and SBF without significant degradation of the scaffold after 35 days, while in NaOH solution, a linear increase of weight lost was observed with preferential degradation of PLLA component. Subsequently, marrow stromal cells (MSC) and human osteoblasts (HOB) reached a plateau at 3 weeks, while at 5 weeks the number of cells was almost the same. Human marrow stromal cell and trabecular osteoblasts rapidly proliferate on the scaffold up to 3 weeks, promoting an oriented migration of bone cells along the fibre arrangement. Moreover, the role of seeded HOB and MSC on composite degradation mechanism was assessed by demonstrating a more relevant contribution to PLLA degradation of MSC when compared to HOB. The novel PCL/PLLA composite scaffolds thus showed promise whenever tuneable porosity, controlled degradability and guided cell–material interaction are simultaneously requested. (literal)
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