Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Coccoli V.; Luciani A.; Orsi S.; Guarino V.; Causa F.; Netti P.A; (2008)
  Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic
  in Journal of materials science. Materials in medicine (Dordr., Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Coccoli V.; Luciani A.; Orsi S.; Guarino V.; Causa F.; Netti P.A; (literal)

Pagina inizio

• 1587 (literal)

Pagina fine

• 1593 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Journal of materials science. Materials in medicine (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Interdisciplinary Research Centre in Biomaterials (CRIB), A4 University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli (literal)

Titolo

• Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic (literal)

Abstract

• Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therapeutic agents. The aim of this work was to modulate the microporosity of poly(e-caprolactone) (PCL) microcarriers to control protein loading capability and release profile. PCL microparticles loaded with BSA (bovine serum albumin) have been de novo synthesized with double emulsion solvent evaporation techniques transferred and adapted for different polymer concentrations (1.7 and 3% w/v) and stabilizer present in the inner aqueous phase (0.05, 0.5 and 1% w/v). SEM (scanning electron microscope) and CLSM (confocal laser scanning 22 microscope) analysis map the drug distribution in homogeneously distributed cavities inside the microspheres with dimensions that can be modulated by varying double emulsion process parameters. The inner structure of BSA-loaded microspheres is greatly affected by the surfactant 27 concentration in the internal aqueous phase, while a slight 28 influence of polymer concentration in the oil phase was observed. The surfactant concentration mainly determines microspheres morphology, as well as drug release kinetics, as confirmed by our in-vitro BSA release study. Moreover, the entrapped protein remained unaltered during the protein encapsulation process, retaining its bio-activity and structure, as shown through a dedicated gel chromatographic analytical method. (literal)

Prodotto di

• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)
• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• VINCENZO GUARINO (Persona)

Insieme di parole chiave

• Parole chiave di "Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR di

• VINCENZO GUARINO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of materials science. Materials in medicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "Engineering of poly(µ-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic" (Insieme di parole chiave)