2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• 2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE (Articolo in rivista) (literal)

Anno

• 1994-01-01T00:00:00+01:00 (literal)

Alternative label

• ALTAMURA, N; DUJARDIN, G; GROUDINSKY, O; SLONIMSKI, PP (1994)
  2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE
  in MGG. Molecular & general genetics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• ALTAMURA, N; DUJARDIN, G; GROUDINSKY, O; SLONIMSKI, PP (literal)

Pagina inizio

• 49 (literal)

Pagina fine

• 56 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 242 (literal)

Rivista

• MGG. Molecular & general genetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Centre National de la Recherche Scientifique (CNRS) (literal)

Titolo

• 2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE (literal)

Abstract

• We previously isolated a nuclear 5.7 kb genomic fragment carrying the NAM7/UPF1 gene, which is able to suppress mitochondrial splicing deficiency when present in multiple copies. We show here that an immediately adjacent gene ISF1 (Increasing Suppression Factor) increases the efficiency of the NAM7/UPF1 suppressor activity. The ISF1 gene has been independently isolated as the MBR3 gene and comparison of the ISF1 predicted protein sequence with data libraries revealed a significant similarity with the MBR1 yeast protein. The ISF1 and NAM7 genes are transcribed in the same direction, and RNase mapping allowed the precise location of their termini within the intergenic region to be determined. The ISF1 gene is not essential for cell viability or respiratory growth. However as for many mitochondrial genes, ISF1 expression is sensitive to fermentative repression; in contrast expression of the NAM7 gene is unaffected by glucose. We propose that ISF1 could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover, thus modulating the expression of nuclear genes involved in mitochondrial biogenesis. (literal)

Prodotto di

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR

• NICOLA ALTAMURA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Sistemi boenergetici di membrana: meccanismi funzionali e fisiopatologia. (SV.P14.005.001) (Modulo)

Autore CNR di

• NICOLA ALTAMURA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• MGG. Molecular & general genetics (Rivista)

Insieme di parole chiave di

• Parole chiave di "2 ADJACENT NUCLEAR GENES, ISF1 AND NAM7/UPF1, COOPERATIVELY PARTICIPATE IN MITOCHONDRIAL FUNCTIONS IN SACCHAROMYCES-CEREVISIAE" (Insieme di parole chiave)