Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells. (Articolo in rivista) (literal)

Anno

• 1986-01-01T00:00:00+01:00 (literal)

Alternative label

• Grimaldi, Giovanna; Di Fiore, Pier Paolo; Locatelli, E. K.; Falco, Joseph P.; Blasi, Francesco (1986)
  Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Grimaldi, Giovanna; Di Fiore, Pier Paolo; Locatelli, E. K.; Falco, Joseph P.; Blasi, Francesco (literal)

Pagina inizio

• 855 (literal)

Pagina fine

• 861 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-0022720812&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• EMBO journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• International Institute of Genetics and Biophysics, CNR; Laboratory of Cellular and Molecular Biology, NCI, NIH (literal)

Titolo

• Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells. (literal)

Abstract

• We have investigated the regulation of urokinase (u-PA) mRNA in quiescent mouse fibroblasts and keratinocytes stimulated to divide by the addition of serum or epidermal growth factor (EGF), respectively. Serum stimulation of quiescent fibroblasts (BALB/c 3T3 or Swiss 3T3) results in an early and transient increase of u-PA mRNA level, which precedes by several hours the onset of DNA synthesis. A similar response is elicited by EGF stimulation of quiescent keratinocytes. The increase of u-PA mRNA parallels that of c-myc mRNA, does not require protein synthesis and is at least in part due to increase in template activity of the u-PA gene. Induction of terminal differentiation of mouse keratinocytes results in a decrease of u-PA mRNA which parallels the decrease of thymidine incorporation. In conclusion, variation in the level of u-PA mRNA is seen during G0/G1 transition and correlates with the proliferative state of these normal mouse cells. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• GIOVANNA GRIMALDI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR di

• GIOVANNA GRIMALDI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)