Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cmet.2014.10.009 (literal)

Alternative label

• Dentice, Monica; Ambrosio, Raffaele; Damiano, Valentina; Sibilio, Annarita; Luongo, Cristina; Guardiola, Ombretta; Yennek, Siham; Zordan, Paola; Minchiotti, Gabriella; Colao, Annamaria; Marsili, Alessandro; Brunelli, Silvia; Del Vecchio, Luigi; Larsen, P. Reed; Tajbakhsh, Shahragim; Salvatore, Domenico (2014)
  Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression
  in Cell metabolism
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dentice, Monica; Ambrosio, Raffaele; Damiano, Valentina; Sibilio, Annarita; Luongo, Cristina; Guardiola, Ombretta; Yennek, Siham; Zordan, Paola; Minchiotti, Gabriella; Colao, Annamaria; Marsili, Alessandro; Brunelli, Silvia; Del Vecchio, Luigi; Larsen, P. Reed; Tajbakhsh, Shahragim; Salvatore, Domenico (literal)

Pagina inizio

• 1038 (literal)

Pagina fine

• 1048 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• Cell metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Naples Federico II; IRCCS SDN; Consiglio Nazionale delle Ricerche (CNR); Institut Pasteur Paris; Vita-Salute San Raffaele University; Harvard University; Harvard University; University of Milano-Bicocca; CEINGE Biotecnol Avanzate Scarl (literal)

Titolo

• Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression (literal)

Abstract

• Precise control of the thyroid hormone (T3)-dependent transcriptional program is required by multiple cell systems, including muscle stem cells. Deciphering how this is achieved and how the T3 signal is controlled in stem cell niches is essentially unknown. We report that in response to proliferative stimuli such as acute skeletal muscle injury, type 3 deiodinase (D3), the thyroid hormone-inactivating enzyme, is induced in satellite cells where it reduces intracellular thyroid signaling. Satellite cell-specific genetic ablation of dio3 severely impairs skeletal muscle regeneration. This impairment is due to massive satellite cell apoptosis caused by exposure of activated satellite cells to the circulating TH. The execution of this proapoptotic program requires an intact FoxO3/MyoD axis, both genes positively regulated by intracellular TH. Thus, D3 is dynamically exploited in vivo to chronically attenuate TH signaling under basal conditions while also being available to acutely increase gene programs required for satellite cell lineage progression. (literal)

Prodotto di

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR

• GABRIELLA MINCHIOTTI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Identificazione di regolatori del differenziamento, della motilità e dell'apoptosi delle cellule staminali (SV.P15.008.001) (Modulo)

Autore CNR di

• GABRIELLA MINCHIOTTI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell metabolism (Rivista)