Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.biomaterials.2007.06.007 (literal)

Alternative label

• A. Borzacchiello; L. Mayol; P.A. Ramires; C. Di Bartolo; A. Pastorello; L. Ambrosio; E. Milella (2007)
  Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering
  in Biomaterials
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. Borzacchiello; L. Mayol; P.A. Ramires; C. Di Bartolo; A. Pastorello; L. Ambrosio; E. Milella (literal)

Pagina inizio

• 4399 (literal)

Pagina fine

• 4408 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• Biomaterials (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IMCB—CNR, P.le Tecchio 80, 80125 Naples, Italy E. Milella, Technological District on Polymeric and Composite Materials Engineering and Structures—IMAST—P.le E. Fermi 1, Portici-Naples, Italy L. Mayol, School of Biotechnological Sciences, Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy C. Di Bartolo, A. Pastorello, Fidia Advanced Biopolymers, via Ponte della Fabbrica 33/b, 35031 Abano T. (PD), Italy (literal)

Titolo

• Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering (literal)

Abstract

• In this study the attention has been focused on the ester derivative of hyaluronic acid (HA), HYAFF®11, as a potential 3D scaffold in adipose tissue engineering. Different HYAFF®11 sponges having different pore sizes, coated or not coated with HA, have been studied from a rheological and morphological point of view in order to correlate their structure to the macroscopic and degradation properties both in vitro and in vivo, using rat model. The in vitro results indicate that the HYAFF®11 sponges posses proper structural and mechanical properties to be used as scaffolds for adipose tissue engineering and, among all the analysed samples, uncoated HYAFF®11 large pore sponges showed a longer lasting mechanical stability. From the in vivo results it was observed that the elastic modulus of scaffolds seeded with pre adipocytes, the biohybrid constructs, and explanted after 3 months of implantation in autologous rat model are over one order of magnitude higher than the corresponding value for the native tissue. These results could suggest that the implanted scaffolds can be invaded and populated by different cells, not only adipocytes, that can produce new matrix having different properties from that of adipose tissue. (literal)

Prodotto di

• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)
• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• ASSUNTA BORZACCHIELLO (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)
• EVELINA MILELLA (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ASSUNTA BORZACCHIELLO (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)
• EVELINA MILELLA (Unità di personale interno)

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomaterials (Rivista)

Insieme di parole chiave di

• Keywords of "Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering" (Insieme di parole chiave)