Tobramycin is a suppressor of premature termination codons (Articolo in rivista)

Type
Label
  • Tobramycin is a suppressor of premature termination codons (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jcf.2013.02.007 (literal)
Alternative label
  • Altamura, Nicola; Castaldo, Rosa; Finotti, Alessia; Breveglieri, Giulia; Salvatori, Francesca; Zuccato, Cristina; Gambari, Roberto; Panin, Giulia Chiara; Borgatti, Monica (2013)
    Tobramycin is a suppressor of premature termination codons
    in Journal of cystic fibrosis
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Altamura, Nicola; Castaldo, Rosa; Finotti, Alessia; Breveglieri, Giulia; Salvatori, Francesca; Zuccato, Cristina; Gambari, Roberto; Panin, Giulia Chiara; Borgatti, Monica (literal)
Pagina inizio
  • 806 (literal)
Pagina fine
  • 811 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://scholar.google.it/citations?view_op=view_citation&hl=it&user=woHO9DIAAAAJ&sortby=pubdate&citation_for_view=woHO9DIAAAAJ:roLk4NBRz8UC (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • Google Schola (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consiglio Nazionale delle Ricerche; University of Ferrara (literal)
Titolo
  • Tobramycin is a suppressor of premature termination codons (literal)
Abstract
  • Premature translation terminations (PTCs) constitute the molecular basis of many genetic diseases, including cystic fibrosis, as they lead to the synthesis of truncated non-functional or partially functional protein. Suppression of translation terminations at PTCs (read-through) has been developed as a therapeutic strategy to restore full-length protein in several genetic diseases. Phenotypic consequences of PTCs can be exacerbated by the nonsense-mediated mRNA decay (NMD) pathway that detects and degrades mRNA containing PTC. Modulation of NMD, therefore, is also of interest as a potential target for the suppression therapy. Tobramycin is an aminoglycoside antibiotic, normally used to treat Pseudomonas aeruginosa pulmonary infection in CF patients. In the present study, by using yeast as a genetic system, we have examined the ability of Tobramycin to suppress PTCs as a function of the presence or absence of NMD. Results demonstrate that Tobramycin exhibits read-through ability on PTCs and preferentially in absence of NMD. © 2013 European Cystic Fibrosis Society. (literal)
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