A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s004150050517 (literal)

Alternative label

• Quattrone, A; Gambardella, A; Carbone, AM; Oliveri, RL; Lavano, A; De Marco, EV; Civitelli, D; Bono, F; Zappia, M; Pardatscher, K; DiMinno, G (1999)
  A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension
  in Journal of neurology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Quattrone, A; Gambardella, A; Carbone, AM; Oliveri, RL; Lavano, A; De Marco, EV; Civitelli, D; Bono, F; Zappia, M; Pardatscher, K; DiMinno, G (literal)

Pagina inizio

• 1086 (literal)

Pagina fine

• 1089 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 246 (literal)

Rivista

• Journal of neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Fac Med & Chirurg; Sch Med Palermo; Sch Med; Natl Res Council; Sch Med (literal)

Titolo

• A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension (literal)

Abstract

• Evidence suggests that isolated intracranial hypertension (ilH) is often associated with cerebral venous thrombosis (CVT). In eight patients referred to our Institution for iIH who were later shown to harbor CVT we have performed a comprehensive coagulation work-up, including genetic tests for inherited predisposition to thrombophilia, to clarify the etiology of sinus venous thrombosis. All subjects were women. All but one were overweight. There were high, plasma concentrations of D dimer, thrombin-antithrombin complexes or prothrombin fragments I and 2, further supporting the neuroimaging diagnosis of CVT. Importantly, seven of eight cases had a raised level of plasminogen activator inhibitor I, a well known inhibitor of fibrinolysis related to obesity: Tissue plasminogen activator levels were elevated accordingly. Factor V gene mutation was present in one subject, and the 20210 prothrombin gene mutation was found in another individual. Three patients had elevated plasmatic levels of homocysteine. In conclusion, the present study provides solid evidence that impaired fibrinolysis probably related to overweight, acting in concert with other prothrombotic abnormalities, is involved in the pathogenesis of CVT presenting as iIH. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• DONATELLA CIVITELLI (Unità di personale interno)
• ELVIRA VALERIA DE MARCO (Persona)

Insieme di parole chiave

• Parole chiave di "A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ELVIRA VALERIA DE MARCO (Persona)
• DONATELLA CIVITELLI (Unità di personale interno)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurology (Rivista)

Insieme di parole chiave di

• Parole chiave di "A hypofibrinolytic state in overweight patients with cerebral venous thrombosis and isolated intracranial hypertension" (Insieme di parole chiave)