Hyaluronic acid hydrogel in the treatment of osteoarthritis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Hyaluronic acid hydrogel in the treatment of osteoarthritis (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Barbucci R., Lamponi S., Borzacchiello A., Ambrosio L. , Fini M., Torricelli P., Giardino R. (2002)
  Hyaluronic acid hydrogel in the treatment of osteoarthritis
  in Biomaterials
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Barbucci R., Lamponi S., Borzacchiello A., Ambrosio L. , Fini M., Torricelli P., Giardino R. (literal)

Pagina inizio

• 4503 (literal)

Pagina fine

• 4513 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• The results obtained by an interdisciplinary research permit to obtain a new material for the treatement of osteoarthritis (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Biomaterials (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• new viscoelastic hydrogel based on crosslinked hyaluronic acid for the treatement of osteoarthritis was synthetised and characterized. The new materials have longer residence time than linear hyaluronic acid while preserving the biocompatibility properties (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 University of Siena, Italy. 2 Institute of Composite and Biomedical 3 Rizzoli Orthopaedic Institute (literal)

Titolo

• Hyaluronic acid hydrogel in the treatment of osteoarthritis (literal)

Abstract

• In order to overcome the problem of rapid clearance of the polysaccharide hyaluronic acid (Hyal) in the treatment of osteoarthritis (OA), a 50% cross-linked Hyal hydrogel (Hyal 50%) was synthesised. The 50% refers to the amount of COOH groups of the polysaccharide involved in the cross-linking reaction. i.e. 50% of the total amount. The rheological behaviour of the Hyal 50% hydrogel, and in particular the possibility to inject it through a needle, was studied. The results obtained demonstrated that the hydrogel injected through the needle still behaved like a gel, although it showed a reduction of the dynamic moduli. The most appropriate sterilisation technique for this kind of hydrogel was also evaluated. Liophilised Hyal 50% samples were sterilised by steam, Ethylene Oxide (EtO) and gamma-rays. EtO and gamma-rays did not modify the characteristics of the hydrogel in terms of swellability and morphology. Lastly, the in vivo effect of Hyal 50% hydrogel in the treatment of chondral defect in rabbit knee was also studied. The results obtained showed the Hyal 50% injections improved chondrocytes density and matrix appearance. Furthermore, the permanence in situ of the hydrogel was longer than that of the linear Hyal. (literal)

Prodotto di

• Institute for composite and biomedical materials (IMCB) (Istituto)

Autore CNR

• ASSUNTA BORZACCHIELLO (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Hyaluronic acid hydrogel in the treatment of osteoarthritis" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ASSUNTA BORZACCHIELLO (Unità di personale interno)
• LUIGI AMBROSIO (Unità di personale interno)

Prodotto

• Institute for composite and biomedical materials (IMCB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomaterials (Rivista)

Insieme di parole chiave di

• Keywords of "Hyaluronic acid hydrogel in the treatment of osteoarthritis" (Insieme di parole chiave)